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Elezanumab (Synonyms: AE12-1Y-QL, ABT-555)
Catalog No. T76863 Copy Product Info
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Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions.
Elezanumab
Copy Product Info🥰Excellent
Catalog No. T76863
Synonyms AE12-1Y-QL, ABT-555
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions.
Cas No. 1791416-49-3
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 5 mg | $689 | In Stock | In Stock | |
| 10 mg | $1,090 | - | In Stock | |
| 25 mg | $1,660 | - | In Stock | |
| 50 mg | $2,230 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.2% (SDS-PAGE); 98.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions. |
| In vivo | Elezanumab (1-10 mg/kg; IV; weekly; 5 times) promotes axonal regeneration and prevents axonal regeneration in the female Lewis rat model of optic nerve crush and optic neuritis Retinal nerve fiber layer degeneration.[1] Elezanumab (0.01, 0.1, 1, 10 mg/kg; IV; once weekly; 3 times) promotes axonal regeneration in a spine-targeted female Lewis rat model of experimental autoimmune encephalomyelitis (EAE) and remyelination, reducing the area of inflammatory lesions and improving functional recovery.[1] |
| Synonyms | AE12-1Y-QL, ABT-555 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | RGMA |
| Molecular Weight | 143.43 kDa |
| Cas No. | 1791416-49-3 |
| Isotype | IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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