store at low temperature
store at -20°C
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 289.00 | |
5 mg | In stock | $ 755.00 | |
10 mg | In stock | $ 1,180.00 |
Description | Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions. |
In vivo |
Elezanumab (1-10 mg/kg; IV; weekly; 5 times) promotes axonal regeneration and prevents axonal regeneration in the female Lewis rat model of optic nerve crush and optic neuritis Retinal nerve fiber layer degeneration.[1] Elezanumab (0.01, 0.1, 1, 10 mg/kg; IV; once weekly; 3 times) promotes axonal regeneration in a spine-targeted female Lewis rat model of experimental autoimmune encephalomyelitis (EAE) and remyelination, reducing the area of inflammatory lesions and improving functional recovery.[1] |
Synonyms | AE12-1Y-QL, ABT-555 |
Molecular Weight | N/A |
CAS No. | 1791416-49-3 |
store at low temperature
store at -20°C
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Elezanumab 1791416-49-3 Stem Cells TGF-beta/Smad AE12-1Y-QL ABT 555 ABT-555 ABT555 inhibitor inhibit