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Oleclumab
(Synonyms: MEDI-9447, MEDI9447, MED I9447) Copy Product Info
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Synonyms: MEDI-9447, MEDI9447, MED I9447
Catalog No. T76695 Copy Product Info
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Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.
Oleclumab
Cas No. 1803176-05-7
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $479 | In Stock | In Stock | |
| 5 mg | $1,180 | In Stock | In Stock | |
| 10 mg | $1,620 | - | In Stock | |
| 25 mg | $2,380 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer. |
| In vivo | In the Murine Balb/c syngeneic CT26 colon carcinoma tumor model, intraperitoneal administration of Oleclumab (10 mg/kg; twice per week for 2 weeks) resulted in a significant inhibition of tumor growth by at least 50% from day 7 to day 16 compared to the isotype control antibody-treated groups[2]. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | MEDI-9447, MEDI9447, MED I9447 |
| Reactivity | Human |
| Verified Activity | Immobilized Mouse NT5E Protein (ECD) at 2 μg/mL (30 μL/well) can bind Oleclumab. The EC50 is 0.001661 μg/mL |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | NT5E/CD73 |
| Molecular Weight | 143.14 kDa |
| Cas No. | 1803176-05-7 |
| Isotype | Human IgG1 lambda2 |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Oleclumab in vivo | Oleclumab molecular weight
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