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Oleclumab
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Catalog No. T76695Cas No. 1803176-05-7
Alias MEDI-9447, MEDI9447, MED I9447
Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.
Oleclumab
Oleclumab
😃Good
Catalog No. T76695Alias MEDI-9447, MEDI9447, MED I9447Cas No. 1803176-05-7
Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $479 | In Stock | In Stock | |
| 5 mg | $1,180 | In Stock | In Stock | |
| 10 mg | $1,620 | - | In Stock | |
| 25 mg | $2,380 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:100% (SEC-HPLC)
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| Description | Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer. |
| In vivo | In the Murine Balb/c syngeneic CT26 colon carcinoma tumor model, intraperitoneal administration of Oleclumab (10 mg/kg; twice per week for 2 weeks) resulted in a significant inhibition of tumor growth by at least 50% from day 7 to day 16 compared to the isotype control antibody-treated groups[2]. |
| Synonyms | MEDI-9447, MEDI9447, MED I9447 |
| Reactivity | Human |
| Verified Activity | Immobilized Mouse NT5E Protein (ECD) at 2 μg/mL (30 μL/well) can bind Oleclumab. The EC50 is 0.001661 μg/mL  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | NT5E/CD73 |
| Molecular Weight | 143.14 kDa |
| Cas No. | 1803176-05-7 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 lambda2 |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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