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Thonzylamine hydrochloride

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Catalog No. T21014Cas No. 63-56-9
Alias Thonzylamine HCl, Resistab, Novohetramin, Neohetramine hydrochloride, Anahist

Thonzylamine hydrochloride (Resistab) is an anticholinergic and antihistamine used as an antipruritic.

Thonzylamine hydrochloride

Thonzylamine hydrochloride

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Purity: 99.67%
Catalog No. T21014Alias Thonzylamine HCl, Resistab, Novohetramin, Neohetramine hydrochloride, AnahistCas No. 63-56-9
Thonzylamine hydrochloride (Resistab) is an anticholinergic and antihistamine used as an antipruritic.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$50In StockIn Stock
10 mg$75In StockIn Stock
25 mg$128In StockIn Stock
50 mg$192In StockIn Stock
100 mg$287In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.67%
Appearance:Solid
Color:Yellow
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Product Introduction

Thonzylamine hydrochloride AI Summary
Thonzylamine hydrochloride exhibits a range of bioactivities with varying degrees of potency. It modulates Lamin A splicing with a potency of 35481.3 nM, inhibits Tau fibril formation with a potency of 158.5 nM, acts as an inhibitor of GCN5L2 at 39810.7 nM, and inhibits the malarial parasite plastid with a potency of 10691.0 nM. It also inhibits the entry of the Ebola Virus with AC50 values spanning from 8.913 µM to 39810.7 nM. Moreover, at a concentration of 10 µM, Thonzylamine hydrochloride inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells by 91.98% and in OATP1B1-transfected CHO cells by 88.59%. The compound shows antiviral activity against SARS-CoV-2, reducing virus-induced cytotoxicity in Caco-2 cells by 4.11% at 10 µM after 48 hours and demonstrating an inhibition of 10.08% against the SARS-CoV-2 3CL-Pro protease at 20 µM. However, it slightly decreases cytotoxicity in VERO-6 cells with an inhibition result of -0.01%..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Thonzylamine hydrochloride (Resistab) is an anticholinergic and antihistamine used as an antipruritic.
SynonymsThonzylamine HCl, Resistab, Novohetramin, Neohetramine hydrochloride, Anahist
Chemical Properties
Molecular Weight322.83
FormulaC16H23ClN4O
Cas No.63-56-9
SmilesCl.N=1C=CC=NC1N(CC2=CC=C(OC)C=C2)CCN(C)C
Relative Density.1.2562 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: Slightly soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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