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Galicaftor
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Catalog No. T22252Cas No. 1918143-53-9
Alias GLPG-2222, GLPG2222, ABBV-2222, ABBV2222
Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector that enhances CFTR protein folding and trafficking, Galicaftor is widely used in cystic fibrosis research to study CFTR rescue mechanisms, epithelial ion transport, and therapeutic correction of underlying molecular defects.
Galicaftor
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Purity: 98.84%
Catalog No. T22252Alias GLPG-2222, GLPG2222, ABBV-2222, ABBV2222Cas No. 1918143-53-9
Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector that enhances CFTR protein folding and trafficking, Galicaftor is widely used in cystic fibrosis research to study CFTR rescue mechanisms, epithelial ion transport, and therapeutic correction of underlying molecular defects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $88 | - | In Stock | |
| 5 mg | $213 | - | In Stock | |
| 10 mg | $347 | - | In Stock | |
| 25 mg | $695 | - | In Stock | |
| 50 mg | $1,090 | - | In Stock | |
| 100 mg | $1,820 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $263 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.84%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector that enhances CFTR protein folding and trafficking, Galicaftor is widely used in cystic fibrosis research to study CFTR rescue mechanisms, epithelial ion transport, and therapeutic correction of underlying molecular defects. |
| In vitro | In cellular assays using primary patient cells homozygous for the F508del/F508del mutation, Galicaftor demonstrates functional restoration of chloride channel activity with an EC₅₀ of < 10 nM [2]. |
| In vivo | In pharmacokinetic studies conducted in rats, Galicaftor has been evaluated for its physiological properties. Following intravenous (i.v.) administration at a dose of 1 mg/kg, the observed half-life (T1/2) is approximately 2.7 h. When administered via the intragastric (oral) route at 1 mg/kg, the molecule exhibits absorption with an oral bioavailability (%F) of 74%. These parameters support the investigation of the molecule in oral dosing regimens within preclinical animal models [1]. |
| Synonyms | GLPG-2222, GLPG2222, ABBV-2222, ABBV2222 |
| Molecular Weight | 559.46 |
| Formula | C28H21F4NO7 |
| Cas No. | 1918143-53-9 |
| Smiles | C(N[C@H]1C=2C(O[C@H](C1)C3=CC=C(C(O)=O)C=C3)=CC(OC(F)F)=CC2)(=O)C4(CC4)C=5C=C6C(=CC5)OC(F)(F)O6 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (143 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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