Shopping Cart

Your shopping cart is currently empty

Galicaftor

Name: Galicaftor
Brand: TargetMol
SKU: T22252
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T22252Cas No. 1918143-53-9

Alias GLPG-2222, GLPG2222, ABBV-2222, ABBV2222

Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector that enhances CFTR protein folding and trafficking, Galicaftor is widely used in cystic fibrosis research to study CFTR rescue mechanisms, epithelial ion transport, and therapeutic correction of underlying molecular defects.

Galicaftor

Copy Product Info

😃Good

Purity: 98.84%

Catalog No. T22252Alias GLPG-2222, GLPG2222, ABBV-2222, ABBV2222Cas No. 1918143-53-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	-	In Stock
5 mg	$213	-	In Stock
10 mg	$347	-	In Stock
25 mg	$695	-	In Stock
50 mg	$1,090	-	In Stock
100 mg	$1,820	-	In Stock
1 mL x 10 mM (in DMSO)	$263	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.84%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector that enhances CFTR protein folding and trafficking, Galicaftor is widely used in cystic fibrosis research to study CFTR rescue mechanisms, epithelial ion transport, and therapeutic correction of underlying molecular defects.
Targets&IC50	Cl- channel:< 10 nM (EC50)
In vitro	In cellular assays using primary patient cells homozygous for the F508del/F508del mutation, Galicaftor demonstrates functional restoration of chloride channel activity with an EC₅₀ of < 10 nM [2].
In vivo	In pharmacokinetic studies conducted in rats, Galicaftor has been evaluated for its physiological properties. Following intravenous (i.v.) administration at a dose of 1 mg/kg, the observed half-life (T1/2) is approximately 2.7 h. When administered via the intragastric (oral) route at 1 mg/kg, the molecule exhibits absorption with an oral bioavailability (%F) of 74%. These parameters support the investigation of the molecule in oral dosing regimens within preclinical animal models [1].
Synonyms	GLPG-2222, GLPG2222, ABBV-2222, ABBV2222

Chemical Properties

Molecular Weight	559.46
Formula	C₂₈H₂₁F₄NO₇
Cas No.	1918143-53-9
Smiles	C(N[C@H]1C=2C(O[C@H](C1)C3=CC=C(C(O)=O)C=C3)=CC(OC(F)F)=CC2)(=O)C4(CC4)C=5C=C6C(=CC5)OC(F)(F)O6
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (143 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7874 mL	8.9372 mL	17.8744 mL	89.3719 mL
5 mM	0.3575 mL	1.7874 mL	3.5749 mL	17.8744 mL
10 mM	0.1787 mL	0.8937 mL	1.7874 mL	8.9372 mL
20 mM	0.0894 mL	0.4469 mL	0.8937 mL	4.4686 mL
50 mM	0.0357 mL	0.1787 mL	0.3575 mL	1.7874 mL
100 mM	0.0179 mL	0.0894 mL	0.1787 mL	0.8937 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc