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Anifrolumab

Catalog No. T77432 CAS 1326232-46-5

Synonyms: MDX-1333, MEDI-546

Anifrolumab（MEDI-546） is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of type I interferon and is used for the prevention and treatment of systemic lupus erythematosus (SLE).

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Anifrolumab

Anifrolumab, CAS 1326232-46-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 197.00
5 mg	In stock	$ 447.00
10 mg	In stock	$ 690.00
25 mg	In stock	$ 1,070.00
50 mg	In stock	$ 1,450.00
100 mg	In stock	$ 1,950.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Anifrolumab（MEDI-546） is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of type I interferon and is used for the prevention and treatment of systemic lupus erythematosus (SLE).
Targets&IC50	ISRE:0.3 nM
In vitro	Anifrolumab induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation at a concentration of 67.7 nM for 20 minutes[1]. Anifrolumab suppresses the differentiation of B cells into plasma cells at concentrations of 1 and 10 μg/mL for 6 or 7 days[1]. Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC50s ranging from 0.004 to 0.3 nM for the IFN-α subtypes, and 0.03 nM and 0.07 nM for IFN-β and IFN-ω, respectively[1].At a concentration of 67.7 nM, Anifrolumab dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α production[1].

Synonyms	MDX-1333, MEDI-546
Molecular Weight	N/A
CAS No.	1326232-46-5

Storage

store at low temperature

store at -80°C

Solubility Information

DMSO: 60 mg/mL (144.07 mM), Sonication is recommended.

References and Literature

1. Riggs JM, et al. Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus. Lupus Sci Med. 2018 Apr 5;5(1):e000261. 2. Furie R, et al. Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017 Feb;69(2):376-386.

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Keywords

Anifrolumab 1326232-46-5 Immunology/Inflammation IFNAR MDX-1333 MDX1333 MEDI546 MDX 1333 MEDI-546 MEDI 546 inhibitor inhibit

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