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GW 833972A

Name: GW 833972A
Brand: TargetMol
SKU: T64394
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64394Cas No. 1092502-33-4

GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.

GW 833972A

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Purity: 99.97%

Catalog No. T64394Cas No. 1092502-33-4

GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	In Stock	In Stock
5 mg	$172	In Stock	In Stock
10 mg	$276	In Stock	In Stock
25 mg	$571	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$168	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.
Targets&IC50	CB2 receptor (rat):7.5 (pEC50), CB2 receptor (human):7.3 (pEC50)
In vitro	GW 833972A (0.3-300 μ M; 10 min) inhibited Capsaicin induced Depolarization of human and guinea pigs, and also inhibited Prostaglandin E (2) and hypertonic saline induced Depolarization of isolated guinea pig Vagus nerve nerve.[1]
In vivo	GW 833972A (30 mg/kg, 2 mL/kg; intraperitoneal injection; single dose, administered 30 minutes before the experiment) inhibits conscious cough symptoms induced by citric acid in guinea pigs and reduces main bronchial blood protein exudation caused by Capsaicin.[1]

Chemical Properties

Molecular Weight	444.24
Formula	C₁₈H₁₄Cl₂F₃N₅O
Cas No.	1092502-33-4
Smiles	Cl.O=C(NCC=1C=CN=CC1)C2=CN=C(N=C2C(F)(F)F)NC=3C=CC=C(Cl)C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (61.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2510 mL	11.2552 mL	22.5104 mL	112.5518 mL
5 mM	0.4502 mL	2.2510 mL	4.5021 mL	22.5104 mL
10 mM	0.2251 mL	1.1255 mL	2.2510 mL	11.2552 mL
20 mM	0.1126 mL	0.5628 mL	1.1255 mL	5.6276 mL
50 mM	0.0450 mL	0.2251 mL	0.4502 mL	2.2510 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc