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GW 833972A

Name: GW 833972A
Brand: TargetMol
SKU: T64394
Price: 178 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T64394Cas No. 1092502-33-4

GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.

GW 833972A

🥰Excellent

Purity: 99.93%

Catalog No. T64394Cas No. 1092502-33-4

GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.

Pack Size	Price	Availability
1 mg	$178	In Stock
5 mg	$452	In Stock
10 mg	$652	In Stock
25 mg	$985	In Stock
1 mL x 10 mM (in DMSO)	$442	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.93%

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COA HPLC

Product Introduction

Bioactivity

Description	GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.
Targets&IC50	CB2 receptor (rat):7.5 (pEC50), CB2 receptor (human):7.3 (pEC50)
In vitro	GW 833972A (0.3-300 μ M; 10 min) inhibited Capsaicin induced Depolarization of human and guinea pigs, and also inhibited Prostaglandin E (2) and hypertonic saline induced Depolarization of isolated guinea pig Vagus nerve nerve.[1]
In vivo	GW 833972A (30 mg/kg, 2 mL/kg; intraperitoneal injection; single dose, administered 30 minutes before the experiment) inhibits conscious cough symptoms induced by citric acid in guinea pigs and reduces main bronchial blood protein exudation caused by Capsaicin.[1]

Chemical Properties

Molecular Weight	444.24
Formula	C₁₈H₁₄Cl₂F₃N₅O
Cas No.	1092502-33-4
Smiles	Cl.O=C(NCC=1C=CN=CC1)C2=CN=C(N=C2C(F)(F)F)NC=3C=CC=C(Cl)C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (61.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2510 mL	11.2552 mL	22.5104 mL	112.5518 mL
5 mM	0.4502 mL	2.2510 mL	4.5021 mL	22.5104 mL
10 mM	0.2251 mL	1.1255 mL	2.2510 mL	11.2552 mL
20 mM	0.1126 mL	0.5628 mL	1.1255 mL	5.6276 mL
50 mM	0.0450 mL	0.2251 mL	0.4502 mL	2.2510 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc