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GW 833972A

Catalog No. T64394 CAS 1092502-33-4

GW 833972A is a selective CB2 receptor agonist.GW 833972A has an inhibitory effect on induced neural depolarization and on citric acid-induced cough in an animal model.

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GW 833972A, CAS 1092502-33-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00
1 mL * 10 mM (in DMSO)	In stock	$ 993.00

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Biological Description

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Description	GW 833972A is a selective CB2 receptor agonist.GW 833972A has an inhibitory effect on induced neural depolarization and on citric acid-induced cough in an animal model.
In vitro	GW 833972A (0.3-300 μ M; 10 min) inhibited Capsaicin induced Depolarization of human and guinea pigs, and also inhibited Prostaglandin E (2) and hypertonic saline induced Depolarization of isolated guinea pig Vagus nerve nerve.[1]
In vivo	GW 833972A (30 mg/kg, 2 mL/kg; intraperitoneal injection; single dose, injected 30 minutes before the start of the experiment) can inhibit conscious cough symptoms induced by citric acid in guinea pigs. It also inhibits the main bronchial Blood protein exudation caused by Capsaicin.[1]

Molecular Weight	727.93
Formula	C44H57NO8
CAS No.	1092502-33-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (37.78 mM)

References and Literature

1. Belvisi MG, et al. Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways. Br J Pharmacol. 2008;155(4):547-557. 2. Takheaw N, et al. Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms. Cells. 2023;12(6):848. 3. Sánchez-Zavaleta R, et al. Presynaptic cannabinoid CB2 receptors modulate [3 H]-Glutamate release at subthalamo-nigral terminals of the rat. Synapse. 2018;72(11):e22061.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GW 833972A 1092502-33-4 GPCR/G Protein Cannabinoid Receptor GW833972A inhibitor inhibit

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