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Mal-L-PA-NH-Boc

Name: Mal-L-PA-NH-Boc
Brand: TargetMol
SKU: T18252
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18252Cas No. 1491152-23-8

Alias mDPR(boc), (S)-MALEOYL-DPR(BOC)-OH·DCHA

Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It forms stable covalent bonds with thiols or amines on antibodies, enhancing ADC stability and targeting。

Mal-L-PA-NH-Boc

🥰Excellent

Purity: 99.09%

Catalog No. T18252Alias mDPR(boc), (S)-MALEOYL-DPR(BOC)-OH·DCHACas No. 1491152-23-8

Pack Size	Price	Availability
10 mg	$30	In Stock
25 mg	$46	In Stock
50 mg	$77	In Stock
100 mg	$118	In Stock
200 mg	$173	In Stock

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Batch Information

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Purity:99.09%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It forms stable covalent bonds with thiols or amines on antibodies, enhancing ADC stability and targeting。
Synonyms	mDPR(boc), (S)-MALEOYL-DPR(BOC)-OH·DCHA

Chemical Properties

Molecular Weight	284.27
Formula	C₁₂H₁₆N₂O₆
Cas No.	1491152-23-8
Smiles	[C@H](CNC(OC(C)(C)C)=O)(C(O)=O)N1C(=O)C=CC1=O
Relative Density.	1.368 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (281.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5178 mL	17.5889 mL	35.1778 mL	175.8891 mL
5 mM	0.7036 mL	3.5178 mL	7.0356 mL	35.1778 mL
10 mM	0.3518 mL	1.7589 mL	3.5178 mL	17.5889 mL
20 mM	0.1759 mL	0.8794 mL	1.7589 mL	8.7945 mL
50 mM	0.0704 mL	0.3518 mL	0.7036 mL	3.5178 mL
100 mM	0.0352 mL	0.1759 mL	0.3518 mL	1.7589 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc