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Lirilumab
(Synonyms: ONO-4483, IPH2102) Copy Product Info
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Synonyms: ONO-4483, IPH2102
Catalog No. T77423 Copy Product Info
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Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical cancer activity of natural killer cells through VAV1-dependent NF-κB deinhibition. It can be used to study leukemia, head and neck squamous cell carcinoma (SCCHN).
Cas No. 1000676-41-4
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $183 | - | In Stock | |
| 5 mg | $463 | In Stock | In Stock | |
| 10 mg | $728 | In Stock | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,480 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.4% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Antibody Information
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| Description | Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical cancer activity of natural killer cells through VAV1-dependent NF-κB deinhibition. It can be used to study leukemia, head and neck squamous cell carcinoma (SCCHN). |
| In vivo | Treatment with Lirilumab (intravenous injection; once; 15 mg/kg) enhances the survival rate of mice injected with tumor[1]. |
| Expression System | CHO |
| Endotoxin | <1.0 EU/mg |
| Synonyms | ONO-4483, IPH2102 |
| Reactivity | Human |
| Verified Activity | Immobilized Human KIR2DL1 Protein (His) (TMPY-02629) at 2 μg/mL (100 μL/well) can bind Lirilumab. The EC50 is 3.92 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | KIR |
| Molecular Weight | 145.52 kDa |
| Cas No. | 1000676-41-4 |
| Isotype | Human IgG4SP kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Lirilumab chemical structure | Lirilumab in vivo | Lirilumab molecular weight
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