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Ociperlimab
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Catalog No. T78324Cas No. 2342597-93-5
Alias WCD-118, WCD118, BGB-A1217, BGBA1217
Ociperlimab (BGB-A1217) is a humanized antibody targeting TIGIT with antitumor activity. It blocks the TIGIT-PVR interaction and is used in the study of advanced solid tumors.
Ociperlimab
Ociperlimab
😃Good
Catalog No. T78324Alias WCD-118, WCD118, BGB-A1217, BGBA1217Cas No. 2342597-93-5
Ociperlimab (BGB-A1217) is a humanized antibody targeting TIGIT with antitumor activity. It blocks the TIGIT-PVR interaction and is used in the study of advanced solid tumors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $228 | - | In Stock | |
| 5 mg | $742 | - | In Stock | |
| 10 mg | $1,180 | - | In Stock | |
| 25 mg | $1,770 | - | In Stock | |
| 50 mg | $2,380 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.17% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
| Description | Ociperlimab (BGB-A1217) is a humanized antibody targeting TIGIT with antitumor activity. It blocks the TIGIT-PVR interaction and is used in the study of advanced solid tumors. |
| Targets&IC50 | TIGIT:0.135 nM (Kd) |
| In vitro | Treatment with Ociperlimab (0-10 μg/mL) increased the secretion of IFN-γ by cytomegalovirus-specific T cells. Ociperlimab (1-1000 ng/mL) activates natural killer cells and monocytes in an FC-dependent manner. Ociperlimab removes TIGIT from the surface of T cells through FC-dependent endocytosis in vitro. [1] |
| In vivo | Ociperlimab (3 and 10 mg/kg; Intrabitoneal injection) in CT26 WT tumor-bearing human TIGIT knockout mice and MC38 tumor-bearing human TIGIT knockout mice showed that Ociperlimab produced anti-tumor effects in an FC-dependent manner. [1] |
| Synonyms | WCD-118, WCD118, BGB-A1217, BGBA1217 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TIGIT/VSIG9/VSTM3 |
| Molecular Weight | 145.12 kDa |
| Cas No. | 2342597-93-5 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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