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Ociperlimab

Catalog No. T78324 CAS 2342597-93-5

Synonyms: BGB-A1217

Ociperlimab, a humanized IgG1 anti-TIGIT antibody, exhibits high affinity for the extracellular domain of human TIGIT, with a dissociation constant (K_D) of 0.135 nM. It effectively inhibits the interaction between TIGIT and its ligands PVR or PVR-L2, and is utilized in cancer research [1] [2].

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Ociperlimab

Ociperlimab, CAS 2342597-93-5

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Description	Ociperlimab, a humanized IgG1 anti-TIGIT antibody, exhibits high affinity for the extracellular domain of human TIGIT, with a dissociation constant (K_D) of 0.135 nM. It effectively inhibits the interaction between TIGIT and its ligands PVR or PVR-L2, and is utilized in cancer research [1] [2].
In vitro	Ociperlimab (BGB-A1217; 0-10 μg/mL) enhances the secretion of IFN-γ by cytomegalovirus-specific T cells [1]. At concentrations of 1-1000 ng/mL, ociperlimab activates natural killer cells and monocytes in an Fc-dependent manner [1]. Additionally, ociperlimab removes TIGIT from the surface of T cells through Fc-dependent endocytosis in vitro [1].
In vivo	Ociperlimab (BGB-A1217; doses of 3 and 10 mg/kg; administered intraperitoneally) elicits antitumor efficacy through an Fc-dependent mechanism in CT26 WT and MC38 tumor-bearing humanized TIGIT-knockin mice [1].

Synonyms	BGB-A1217
Molecular Weight	N/A
CAS No.	2342597-93-5

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ociperlimab 2342597-93-5 BGB-A-1217 BGB-A 1217 BGB-A1217 inhibitor inhibit

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