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Isonipecotic acid

Name: Isonipecotic acid
Brand: TargetMol
SKU: T22348
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22348Cas No. 498-94-2

Alias Hexahydroisonicotinic acid, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine

Isonipecotic acid (4-Piperidinecarboxylic acid) is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.

Isonipecotic acid

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Purity: 99.82%

Catalog No. T22348Alias Hexahydroisonicotinic acid, 4-Piperidinecarboxylic acid, 4-CarboxypiperidineCas No. 498-94-2

Isonipecotic acid (4-Piperidinecarboxylic acid) is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.82%

Appearance:solid

Color:White

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COA HNMR LCMS

Product Introduction

Isonipecotic acid AI Summary

Isonipecotic acid exhibits a wide range of bioactivities. It acts as an agonist on human Gamma-aminobutyric acid A (GABAA) receptor subtypes, demonstrating varying potency (EC50 values) on subtypes such as alpha-1-beta-3-gamma-2, alpha-2-beta-3-gamma-2, alpha-3-beta-3-gamma-2, alpha-4-beta-3-gamma-2, alpha-5-beta-3-gamma-2, and alpha-6-beta-3-gamma-2. It also shows agonist activity against the GABA-C receptor derived from bovine retinal RNA with a binding affinity (Kb) greater than 100,000 nM and significant inhibitory effects on GABA binding in rat brain synaptosomal membranes with an IC50 of 330 nM. Despite its extensive receptor interactions, Isonipecotic acid shows weak anticonvulsive activity in the bicuculline (BIC) test, with an effective dose (ED50) of greater than 1000 umol.kg-1. Additionally, it demonstrates inhibitory activity against the N-methyl-D-aspartate glutamate receptor 1 with an IC50 of 94100 nM and has distinct effects on the input resistance of cultured spinal cord neurons. Furthermore, Isonipecotic acid exhibits antiplasmodial activity against Plasmodium falciparum with an IC50 of 15848.93 nM and differential inhibition of various Plasmodium falciparum strains. It also modulates activity for several other receptors and enzymes such as Thyroid Stimulating Hormone Receptor, Human Peripheral Myelin Protein 22 (PMP22), Acetylcholine Muscarinic M1 Receptor, and other enzymes like Histone Lysine Methyltransferase G9a and Mammalian Selenoprotein Thioredoxin Reductase 1. Additionally, it shows inhibition of virus entry for Lassa Virus and Marburg Virus and enhances Arylsulfatase A (ASA1) activity. In terms of neuronal interactions, Isonipecotic acid exhibits moderate affinity for GABAA receptors with Ki values around 500 nM and acts as an agonist at several subtypes with varying EC50 values, demonstrating considerable efficacy compared to GABA. It also moderately inhibits human PAT1-mediated L-[3H]proline uptake in human Caco2 cells with a Ki value of 2300000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isonipecotic acid (4-Piperidinecarboxylic acid) is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.
Synonyms	Hexahydroisonicotinic acid, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine

Chemical Properties

Molecular Weight	129.16
Formula	C₆H₁₁NO₂
Cas No.	498-94-2
Smiles	OC(=O)C1CCNCC1
Relative Density.	1.125 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25 mg/mL (193.56 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	7.7423 mL	38.7117 mL	77.4234 mL	387.1168 mL
5 mM	1.5485 mL	7.7423 mL	15.4847 mL	77.4234 mL
10 mM	0.7742 mL	3.8712 mL	7.7423 mL	38.7117 mL
20 mM	0.3871 mL	1.9356 mL	3.8712 mL	19.3558 mL
50 mM	0.1548 mL	0.7742 mL	1.5485 mL	7.7423 mL
100 mM	0.0774 mL	0.3871 mL	0.7742 mL	3.8712 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc