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Sp-8-CPT-cAMPS

Catalog No. T38694 CAS 129693-13-6

Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.

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Sp-8-CPT-cAMPS, CAS 129693-13-6

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Description

In vitro

Sp-8-CPT-cAMPS at a concentration of 100 μM and duration of 24 hours notably amplifies IL-1β-induced nitrite release in vascular smooth muscle cells, augmenting this release threefold even without IL-1β presence. Additionally, it boosts the expression of iNOS protein in rat aortic smooth muscle cells under the same conditions [2]. At a lower concentration and shorter exposure (10 μM; 30 min), Sp-8-CPT-cAMPS demonstrates anti-spasmogenic properties by reducing acetylcholine (ACh)-induced tension in guinea-pig trachealis [3].

Molecular Weight	487.87
Formula	C16H15ClN5O5PS2
CAS No.	129693-13-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. 2. Boese M, et, al. Effect of cyclic GMP-dependent vasodilators on the expression of inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP. Br J Pharmacol. 1996 Oct;119(4):707-15. 3. Spicuzza L, et, al. Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol. 2001 Aug;133(8):1201-12.

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Keywords

Sp-8-CPT-cAMPS 129693-13-6 Sp 8 CPT cAMPS Sp8CPTcAMPS inhibitor inhibit

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