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Sp-8-CPT-cAMPS

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Catalog No. T38694Cas No. 129693-13-6

Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.

Sp-8-CPT-cAMPS

Sp-8-CPT-cAMPS

😃Good
Catalog No. T38694Cas No. 129693-13-6
Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.
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Product Introduction

Bioactivity
Description
Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.
In vitro
Sp-8-CPT-cAMPS at a concentration of 100 μM and duration of 24 hours notably amplifies IL-1β-induced nitrite release in vascular smooth muscle cells, augmenting this release threefold even without IL-1β presence. Additionally, it boosts the expression of iNOS protein in rat aortic smooth muscle cells under the same conditions [2]. At a lower concentration and shorter exposure (10 μM; 30 min), Sp-8-CPT-cAMPS demonstrates anti-spasmogenic properties by reducing acetylcholine (ACh)-induced tension in guinea-pig trachealis [3].
Chemical Properties
Molecular Weight487.87
FormulaC16H15ClN5O5PS2
Cas No.129693-13-6
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

Sp-8-CPT-cAMPSSp8CPTcAMPSSp 8 CPT cAMPS
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