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Umbelopsisin A
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Catalog No. TN13293 Copy Product Info
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Umbelopsisin A is a non-selective agonist of GABAA and GABAB receptors. It activates GABAergic pathways, including the Notch signaling pathway and fatty acid metabolism. Umbelopsisin A exhibits dual neuroprotective effects against excitotoxicity of glutamate both in vitro (reducing reactive oxygen species (ROS) and cell death) and in vivo. It is applicable for research in glaucoma and other neurodegenerative diseases.
Umbelopsisin A
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Umbelopsisin A is a non-selective agonist of GABAA and GABAB receptors. It activates GABAergic pathways, including the Notch signaling pathway and fatty acid metabolism. Umbelopsisin A exhibits dual neuroprotective effects against excitotoxicity of glutamate both in vitro (reducing reactive oxygen species (ROS) and cell death) and in vivo. It is applicable for research in glaucoma and other neurodegenerative diseases. |
| In vitro | Umbelopsisin A protects R28 cells from glutamate-induced excitotoxicity and decreases ROS production at concentrations of 0.5 μM to 16 μM over 24 hours in R28 cells. At 2 μM for 24 hours in R28 cells, it regulates gene expression, promoting axonogenesis and pathways related to GABA. Additionally, at concentrations of 20 μM to 400 μM over 24 hours in R28 cells, Umbelopsisin A functions as a GABA receptor agonist, directly binding to GABA_A and GABA_B receptors. |
| In vivo | Umbelopsisin A (20 μM; intravitreal; 1 μL) safeguards retinal ganglion cells (RGC) and enhances visual function in NMDA-induced retinal damage in C57BL/6 mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: Umbelopsisin A in vivo | Umbelopsisin A in vitro
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