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Anabasine

Name: Anabasine
Brand: TargetMol
SKU: T7224
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7224Cas No. 494-52-0

Alias (S)-Anabasine, (-)-Anabasine

Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco, acting as a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. It depolarizes TE671 cells that endogenously express human myotypic nAChRs.

Anabasine

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Purity: 99.98%

Catalog No. T7224Alias (S)-Anabasine, (-)-AnabasineCas No. 494-52-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$129	-	In Stock
100 mg	$228	-	In Stock
200 mg	$342	-	In Stock
1 mL x 10 mM (in DMSO)	$53	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Liquid

Color:Transparent

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco, acting as a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. It depolarizes TE671 cells that endogenously express human myotypic nAChRs.
In vivo	Anabasine significantly reverses impairment at doses of 0.2 mg/kg (p<0.05) and 2 mg/kg (p<0.025), without any significant effects on response latency when administered alone. However, the 0.06 mg/kg Anabasine dose exacerbates dizocilpine-induced impairment, increasing non-response trials significantly (p<0.05), and none of the Anabasine doses affect choice accuracy on their own [2].
Synonyms	(S)-Anabasine, (-)-Anabasine

Chemical Properties

Molecular Weight	162.23
Formula	C₁₀H₁₄N₂
Cas No.	494-52-0
Smiles	C1CC[C@H](NC1)c1cccnc1
Relative Density.	1.0455 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (308.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1641 mL	30.8204 mL	61.6409 mL	308.2044 mL
5 mM	1.2328 mL	6.1641 mL	12.3282 mL	61.6409 mL
10 mM	0.6164 mL	3.0820 mL	6.1641 mL	30.8204 mL
20 mM	0.3082 mL	1.5410 mL	3.0820 mL	15.4102 mL
50 mM	0.1233 mL	0.6164 mL	1.2328 mL	6.1641 mL
100 mM	0.0616 mL	0.3082 mL	0.6164 mL	3.0820 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc