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Tozorakimab
(Synonyms: MEDI-3506, MEDI3506, MEDI 3506) Copy Product Info
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Synonyms: MEDI-3506, MEDI3506, MEDI 3506
Catalog No. T76972 Copy Product Info
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Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting IL-33. It inhibits IL-33 signaling through ST2 and RAGE/EGFR, reduces inflammation and epithelial dysfunction, and can be used to study chronic obstructive pulmonary disease.
Tozorakimab
Cas No. 2376858-66-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 1 mg * 5 | $645 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.5% (SDS-PAGE); 99.8% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting IL-33. It inhibits IL-33 signaling through ST2 and RAGE/EGFR, reduces inflammation and epithelial dysfunction, and can be used to study chronic obstructive pulmonary disease. |
| Targets & IC50 | IL-33:0.082 nM |
| In vitro | Tozorakimab had a > 10,000-fold higher potency for IL-33red than the lead mAb (33v20064) in a biochemical epitope competition assay (IC50=0.082 nM). [1] |
| In vivo | Female humanized IL-33 mice (6–10 weeks of age) were anaesthetized using isoflurane. Prophylactic intraperitoneal administration of Tozorakimab (0.1, 1.0, 3.0 and 10.0 mg/kg) dose-dependently inhibited IL-5 levels in bronchoalveolar lavage fluid (BALF) compared with the controls. [1] |
| Endotoxin | <1.0 EU/mg |
| Synonyms | MEDI-3506, MEDI3506, MEDI 3506 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IL-33 Protein (TMPY-00861) at 1 μg/mL (100 μL/well) can bind Tozorakimab. The EC50 is 2.70 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IL-33 |
| Molecular Weight | 144.65 kDa |
| Cas No. | 2376858-66-9 |
| Isotype | Human IgG1 lambda2 |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Tozorakimab in vivo | Tozorakimab in vitro | Tozorakimab molecular weight
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