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ODN 1826 sodium
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Catalog No. T212687
Alias CpG 1826 sodium
ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) and a TLR9 agonist. It induces the production of NO and iNOS and enhances apoptosis. ODN 1826 sodium boosts immune surveillance and increases the size of atherosclerotic plaques. It exhibits antitumor activity against lung cancer, glioma, and melanoma.
ODN 1826 sodium
ODN 1826 sodium
Copy Product Info😃Good
Catalog No. T212687Alias CpG 1826 sodium
ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) and a TLR9 agonist. It induces the production of NO and iNOS and enhances apoptosis. ODN 1826 sodium boosts immune surveillance and increases the size of atherosclerotic plaques. It exhibits antitumor activity against lung cancer, glioma, and melanoma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) and a TLR9 agonist. It induces the production of NO and iNOS and enhances apoptosis. ODN 1826 sodium boosts immune surveillance and increases the size of atherosclerotic plaques. It exhibits antitumor activity against lung cancer, glioma, and melanoma. |
| In vitro | ODN 1826 (1 μg/mL; 24 h) sodium stimulates the production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in RAW 264.7 mouse macrophages. |
| In vivo | CpG-1826 (100 μg/tumor; intratumoral injection; up to 4 times every 3 days) sodium can slow the growth of subcutaneously implanted GL261 gliomas in C57BL/6NTac mice by enhancing the infiltration of macrophages and B cells into the tumor, significantly delaying growth in about 50% of the mice. In a model of chronic vascular injury, ODN 1826 (18 nM; subcutaneous injection; thrice weekly for a total of 7 weeks) sodium increases atherosclerotic plaque size in mice. Additionally, ODN 1826 (0.05 mg; intraperitoneal injection; on days 1, 3, 5, 8, 11, 13) sodium exhibits potent anti-tumor growth activity in a Lewis lung carcinoma mouse tumor model. |
| Synonyms | CpG 1826 sodium |
| Storage | Lyophilized powder: -20~-80°C for 1 year |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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