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3-Aminopropylphosphonic Acid

Name: 3-Aminopropylphosphonic Acid
Brand: TargetMol
SKU: T38205
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38205Cas No. 13138-33-5

3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).

3-Aminopropylphosphonic Acid

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Purity: 99.84%

Catalog No. T38205Cas No. 13138-33-5

3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$40	-	In Stock
200 mg	$59	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.84%

Appearance:Solid

Color:Cyan

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).
In vitro	3-aminopropylphosphonic acid (IC50 1.5 microM) and 4-aminobutyl-phosphonic acid (IC50 3.9 μM) were much more potent than anticipated from their relatively weak GABAB antagonist actions [1]. 3-aminopropylphosphonic acid was a potent inhibitor (IC50 6μM) of the binding of [3H]GABA to rat brain membranes under GABAB conditions, i.e. in the presence of 0.1 mM isoguvacine and displaceable by 0.1 mM (+)-baclofen [1].
In vivo	3-aminopropylphosphonic acid induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle. 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs. It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.

Chemical Properties

Molecular Weight	139.09
Formula	C₃H₁₀NO₃P
Cas No.	13138-33-5
Smiles	NCCCP(O)(O)=O
Relative Density.	1.378 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL (1.8 mM), Sonication is recommended.

H2O: 105 mg/mL (754.91 mM), Sonication is recommended.

DMF: 5 mg/mL (35.95 mM), Sonication is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 30 mg/mL (215.69 mM), Sonication is recommended.

Solution Preparation Table

DMF/Ethanol/H2O

	1mg	5mg	10mg	50mg
5 mM	1.4379 mL	7.1896 mL	14.3792 mL	71.8959 mL
10 mM	0.7190 mL	3.5948 mL	7.1896 mL	35.9479 mL
20 mM	0.3595 mL	1.7974 mL	3.5948 mL	17.9740 mL

Ethanol/H2O

	1mg	5mg	10mg	50mg
50 mM	0.1438 mL	0.7190 mL	1.4379 mL	7.1896 mL
100 mM	0.0719 mL	0.3595 mL	0.7190 mL	3.5948 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc