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Rafabegron

Name: Rafabegron
Brand: TargetMol
SKU: T34256
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T34256Cas No. 244081-42-3

Alias TAK-677, TAK677, TAK 677, AD-9677, AD9677, AD 9677

Rafabegron (TAK677) is a potent and selective β3 adrenergic receptor agonist for the study of diabetes and obesity.

Rafabegron

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Purity: 99.81%

Catalog No. T34256Alias TAK-677, TAK677, TAK 677, AD-9677, AD9677, AD 9677Cas No. 244081-42-3

Rafabegron (TAK677) is a potent and selective β3 adrenergic receptor agonist for the study of diabetes and obesity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$290	In Stock	In Stock
5 mg	$713	In Stock	In Stock
10 mg	$987	-	In Stock
25 mg	$1,480	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,730	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

ee:100%

Appearance:Solid

Color:Yellow

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COA LCMS CSFC HNMR ORP

Product Introduction

Rafabegron AI Summary

Rafabegron exhibits potent agonistic activity towards the human beta-3 adrenergic receptor, with an EC50 of 0.062 nM and an intrinsic activity of 116.0%. It also shows moderate agonistic activity towards the human beta-2 adrenergic receptor, with an EC50 of 13.0 nM and an intrinsic activity of 26.0%, and against the human beta-1 adrenergic receptor, with an EC50 of 6.4 nM and an intrinsic activity of 26.0%. Overall, Rafabegron demonstrates strong bioactivity, especially in stimulating the beta-3 adrenergic receptor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Rafabegron (TAK677) is a potent and selective β3 adrenergic receptor agonist for the study of diabetes and obesity.
Synonyms	TAK-677, TAK677, TAK 677, AD-9677, AD9677, AD 9677

Chemical Properties

Molecular Weight	402.87
Formula	C₂₁H₂₃ClN₂O₄
Cas No.	244081-42-3
Smiles	O(CC(O)=O)C1=C2C(C(C[C@H](NC[C@H](O)C3=CC(Cl)=CC=C3)C)=CN2)=CC=C1
Relative Density.	1.345g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (111.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4822 mL	12.4110 mL	24.8219 mL	124.1095 mL
5 mM	0.4964 mL	2.4822 mL	4.9644 mL	24.8219 mL
10 mM	0.2482 mL	1.2411 mL	2.4822 mL	12.4110 mL
20 mM	0.1241 mL	0.6205 mL	1.2411 mL	6.2055 mL
50 mM	0.0496 mL	0.2482 mL	0.4964 mL	2.4822 mL
100 mM	0.0248 mL	0.1241 mL	0.2482 mL	1.2411 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc