IL-15RA Protein, Mouse, Recombinant (hFc)（Human Cells）

Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.

Pack Size	Availability	Price/USD
10 μg	In stock	$ 38.00
20 μg	5 days	$ 54.00
50 μg	5 days	$ 82.00

Pack Size

Availability

Price/USD

Quantity

10 μg

In stock

$ 38.00

20 μg

5 days

$ 54.00

50 μg

5 days

$ 82.00

Biological Information

Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 0.5-2 ng/ml. (QC verified)

Description

Species	Mouse
Expression System	Human Cells
Tag	C-Fc
Accession Number	Q60819
Synonyms	sIL-15 receptor subunit α, Il15ra, Interleukin-15 receptor subunit alpha, Interleukin-15 receptor subunit α, sIL-15 receptor subunit alpha
Amino Acid	Gly33-Lys205
Construction	Recombinant Mouse Interleukin-15 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Gly33-Lys205 is expressed with a human IgG1 Fc tag at the C-terminus.
Molecular Weight	60-90 KDa, reducing conditions

Endotoxin	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Stability & Storage	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background	Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.

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IL-15RA Protein, Mouse, Recombinant (hFc)（Human Cells）

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