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Tildrakizumab (Synonyms: SCH 900222, MK 3222)
Catalog No. T76784 Copy Product Info
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Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody targeting the p19 subunit of IL-23 with a Kd value of 136 pM, useful for studying psoriasis.
Tildrakizumab
Copy Product Info🥰Excellent
Catalog No. T76784
Synonyms SCH 900222, MK 3222
Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody targeting the p19 subunit of IL-23 with a Kd value of 136 pM, useful for studying psoriasis.
Tildrakizumab
Cas No. 1326244-10-3
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $228 | - | In Stock | |
| 5 mg | $745 | In Stock | In Stock | |
| 10 mg | $1,180 | - | In Stock | |
| 25 mg | $1,780 | - | In Stock | |
| 50 mg | $2,380 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:>95% (SDS-PAGE); 99.37% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody targeting the p19 subunit of IL-23 with a Kd value of 136 pM, useful for studying psoriasis. |
| Targets&IC50 | HeLa cells:23 pM |
| In vitro | Tildrakizumab inhibits IL-23-induced STAT3 signaling in HeLa cells expressing human IL-23Rα and IL-12Rβ1 receptors, with an IC50 of 23 pM[2], and reduces the affinity of IL-23 for IL-23Rα through negative allosteric modulation[2]. |
| In vivo | Tildrakizumab (100 mg/kg, subcutaneous injection, every two weeks, up to 9 months) demonstrates good tolerability in cynomolgus monkeys (toxicity study)[3]. |
| Synonyms | SCH 900222, MK 3222 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IL-23 alpha Protein (His) (TMPY-00406) at 1 μg/mL (100 μL/well) can bind Tildrakizumab. The EC50 is 13.13 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IL-23a |
| Molecular Weight | 144.44 kDa |
| Cas No. | 1326244-10-3 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
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