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Tildrakizumab

Catalog No. T76784 CAS 1326244-10-3

Synonyms: MK 3222, SCH 900222

Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody against IL-23 (p19 subunit). Tildrakizumab targets single-stranded IL-23 with a Kd value of 136 pM. Tildrakizumab can be used to study psoriasis and psoriasis.

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Tildrakizumab

Tildrakizumab, CAS 1326244-10-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 328.00
5 mg	In stock	$ 863.00
10 mg	In stock	$ 1,380.00

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Description	Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody against IL-23 (p19 subunit). Tildrakizumab targets single-stranded IL-23 with a Kd value of 136 pM. Tildrakizumab can be used to study psoriasis and psoriasis.
Targets&IC50	HeLa cells:23 pM
In vitro	Tildrakizumab inhibits IL-23-induced STAT3 signaling in HeLa cells expressing human IL-23Rα and IL-12Rβ1 receptors, with an IC50 of 23 pM[2]. Tildrakizumab reduces the affinity of IL-23 for IL-23Rα through negative allosteric modulation[2].
In vivo	Tildrakizumab (100 mg/kg, subcutaneous injection, every two weeks, up to 9 months) demonstrates good tolerability in cynomolgus monkeys (toxicity study)[3].

Synonyms	MK 3222, SCH 900222
Molecular Weight	144.4 (kDa)
CAS No.	1326244-10-3

Storage

store at low temperature

store at -80°C

References and Literature

1. Papp K, et al. Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial. Br J Dermatol. 2015 Oct;173(4):930-9. 2. Zhou L, et al. A non-clinical comparative study of IL-23 antibodies in psoriasis. MAbs. 2021 Jan-Dec;13(1):1964420. 3. Santostefano M, et al. Nonclinical safety of tildrakizumab, a humanized anti-IL-23p19 monoclonal antibody, in nonhuman primates. Regul Toxicol Pharmacol. 2019 Nov;108:104476.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tildrakizumab 1326244-10-3 Immunology/Inflammation IL Receptor MK 3222 MK3222 SCH 900222 SCH900222 MK-3222 SCH-900222 inhibitor inhibit

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