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Tildrakizumab
Tildrakizumab
Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody targeting the p19 subunit of IL-23 with a Kd value of 136 pM, useful for studying psoriasis.
Catalog No. T76784Cas No. 1326244-10-3
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Concentration:6.09 mg/mL
Purity:SDS-PAGE:95% SEC-HPLC:95%
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Tildrakizumab
Catalog No. T76784Cas No. 1326244-10-3
Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody targeting the p19 subunit of IL-23 with a Kd value of 136 pM, useful for studying psoriasis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $328 | In Stock | |
| 5 mg | $863 | In Stock | |
| 10 mg | $1,380 | In Stock |
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody targeting the p19 subunit of IL-23 with a Kd value of 136 pM, useful for studying psoriasis. |
| Targets&IC50 | HeLa cells:23 pM |
| In vitro | Tildrakizumab inhibits IL-23-induced STAT3 signaling in HeLa cells expressing human IL-23Rα and IL-12Rβ1 receptors, with an IC50 of 23 pM[2], and reduces the affinity of IL-23 for IL-23Rα through negative allosteric modulation[2]. |
| In vivo | Tildrakizumab (100 mg/kg, subcutaneous injection, every two weeks, up to 9 months) demonstrates good tolerability in cynomolgus monkeys (toxicity study)[3]. |
| Alias | MK 3222, SCH 900222 |
| Molecular Weight | 144.4 (kDa) |
| Cas No. | 1326244-10-3 |
| Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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