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MS-L6
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Catalog No. T201371Cas No. 63498-32-8
Alias NSC34338, Agn-PC-0N3ahi
MS-L6 is an inhibitor of the mitochondrial respiratory complex I (ETC-I) with uncoupling properties. This product blocks oxidative phosphorylation (OXPHOS) by inhibiting NADH oxidation and exerting uncoupling effects. MS-L6 reduces mitochondrial membrane potential, inhibits ATP production, and induces mitochondrial dysfunction and apoptosis in tumor cells.
MS-L6
😃Good
Purity: 99.98%
Catalog No. T201371Alias NSC34338, Agn-PC-0N3ahiCas No. 63498-32-8
MS-L6 is an inhibitor of the mitochondrial respiratory complex I (ETC-I) with uncoupling properties. This product blocks oxidative phosphorylation (OXPHOS) by inhibiting NADH oxidation and exerting uncoupling effects. MS-L6 reduces mitochondrial membrane potential, inhibits ATP production, and induces mitochondrial dysfunction and apoptosis in tumor cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $41 | - | In Stock | |
| 5 mg | $78 | - | In Stock | |
| 10 mg | $124 | - | In Stock | |
| 25 mg | $249 | - | In Stock | |
| 50 mg | $398 | - | In Stock | |
| 100 mg | $630 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $95 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MS-L6 is an inhibitor of the mitochondrial respiratory complex I (ETC-I) with uncoupling properties. This product blocks oxidative phosphorylation (OXPHOS) by inhibiting NADH oxidation and exerting uncoupling effects. MS-L6 reduces mitochondrial membrane potential, inhibits ATP production, and induces mitochondrial dysfunction and apoptosis in tumor cells. |
| In vitro | In multiple cancer cell lines, MS-L6 dose-dependently reduces oxygen consumption rate (OCR) and ATP levels, triggering mitochondrial membrane potential loss and cytochrome c release to activate caspase-3 and induce apoptosis [1]. |
| In vivo | In pharmacological studies using tumor xenograft mouse models, systemic administration of MS-L6 (at doses such as 10-20 mg/kg) leads to a significant reduction in tumor volume and weight; the treatment results in decreased intratumoral ATP concentrations and increased expression of apoptotic markers, demonstrating effective suppression of tumor progression through mitochondrial metabolic disruption [1]. |
| Synonyms | NSC34338, Agn-PC-0N3ahi |
| Molecular Weight | 548.4 |
| Formula | C20H28Br2N4S2 |
| Cas No. | 63498-32-8 |
| Smiles | N=C(NC1=CC=CC=C1)SCCCCCCSC(NC2=CC=CC=C2)=N.Br.Br |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 3.00 mg/mL (5.47 mM), Sonication is recommended. DMSO: 100.00 mg/mL (182.35 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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