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plCSA-BP

Name: plCSA-BP
Brand: TargetMol
SKU: TP3682
Rating: 4.5 (1 reviews)

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Catalog No. TP3682Cas No. 2294870-89-4

plCSA-BP is a placental CSA-binding peptide that specifically binds to trophoblastic cells without interacting with other cell types in the placenta or with CSA-expressing cells in other tissues. It can direct nanoparticles to deliver payloads, such as Indocyanine green (ICG) and Methotrexate (MTX), for targeted placental drug delivery, highlighting its potential in placenta-specific drug delivery research.

plCSA-BP

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Catalog No. TP3682Cas No. 2294870-89-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

In vivo

plCSA-BP (50 ng/mL) is co-localized with trophoblast cells in mouse placenta at E6.5, E8.5, E10.5, and E12.5, but it does not bind to the embryo, junctional zone, or decidua; similar effects are observed in human placenta. It specifically binds to placental CSA expressed in murine labyrinth and human syncytiotrophoblasts. When plCSA-BP (5 mg/kg, intravenously injected at E12.5 or E15.5) is conjugated to nanoparticles, it specifically delivers ICG to trophoblast cells in pregnant mice at stages E12.5 or E15.5. Additionally, plCSA-BP (5 mg/kg, intravenously injected every other day from E6.5 to E14.5) linked to nanoparticles efficiently targets MTX to placental cells, severely impairing placental and fetal development by targeting placental trophoblast cells.

Chemical Properties

Molecular Weight	3186.61
Formula	C₁₄₂H₂₂₁N₃₅O₄₄S₂
Cas No.	2294870-89-4
Smiles	[C@@H](CC1=CN=CN1)(NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)CC(O)=O)=O)[C@@H](C)C)=O)CCCCN)=O)CC(O)=O)=O)[C@H](CC)C)=O)CC(N)=O)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CCC(O)=O)=O)CCCCN)=O)=O)CC(C)C)=O)C)=O)=O)CS)=O)CC(C)C)=O)[C@H](CC)C)=O)C(C)C)=O)CO)=O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(O)=O)CS)=O)CCCCN)=O)=O)CCC(O)=O)=O
Sequence	Glu-Asp-Val-Lys-Asp-Ile-Asn-Phe-Asp-Thr-Lys-Glu-Lys-Phe-Leu-Ala-Gly-Cys-Leu-Ile-Val-Ser-Phe-His-Glu-Gly-Lys-Cys
Sequence Short	EDVKDINFDTKEKFLAGCLIVSFHEGKC

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc