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plCSA-BP

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Catalog No. TP3682Cas No. 2294870-89-4

plCSA-BP is a placental CSA-binding peptide that specifically binds to trophoblastic cells without interacting with other cell types in the placenta or with CSA-expressing cells in other tissues. It can direct nanoparticles to deliver payloads, such as Indocyanine green (ICG) and Methotrexate (MTX), for targeted placental drug delivery, highlighting its potential in placenta-specific drug delivery research.

plCSA-BP

plCSA-BP

😃Good
Catalog No. TP3682Cas No. 2294870-89-4
plCSA-BP is a placental CSA-binding peptide that specifically binds to trophoblastic cells without interacting with other cell types in the placenta or with CSA-expressing cells in other tissues. It can direct nanoparticles to deliver payloads, such as Indocyanine green (ICG) and Methotrexate (MTX), for targeted placental drug delivery, highlighting its potential in placenta-specific drug delivery research.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
plCSA-BP is a placental CSA-binding peptide that specifically binds to trophoblastic cells without interacting with other cell types in the placenta or with CSA-expressing cells in other tissues. It can direct nanoparticles to deliver payloads, such as Indocyanine green (ICG) and Methotrexate (MTX), for targeted placental drug delivery, highlighting its potential in placenta-specific drug delivery research.
In vivo
plCSA-BP (50 ng/mL) is co-localized with trophoblast cells in mouse placenta at E6.5, E8.5, E10.5, and E12.5, but it does not bind to the embryo, junctional zone, or decidua; similar effects are observed in human placenta. It specifically binds to placental CSA expressed in murine labyrinth and human syncytiotrophoblasts. When plCSA-BP (5 mg/kg, intravenously injected at E12.5 or E15.5) is conjugated to nanoparticles, it specifically delivers ICG to trophoblast cells in pregnant mice at stages E12.5 or E15.5. Additionally, plCSA-BP (5 mg/kg, intravenously injected every other day from E6.5 to E14.5) linked to nanoparticles efficiently targets MTX to placental cells, severely impairing placental and fetal development by targeting placental trophoblast cells.
Chemical Properties
Molecular Weight3186.61
FormulaC142H221N35O44S2
Cas No.2294870-89-4
Smiles[C@@H](CC1=CN=CN1)(NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)CC(O)=O)=O)[C@@H](C)C)=O)CCCCN)=O)CC(O)=O)=O)[C@H](CC)C)=O)CC(N)=O)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CCC(O)=O)=O)CCCCN)=O)=O)CC(C)C)=O)C)=O)=O)CS)=O)CC(C)C)=O)[C@H](CC)C)=O)C(C)C)=O)CO)=O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(O)=O)CS)=O)CCCCN)=O)=O)CCC(O)=O)=O
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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