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CXCL2 Protein, Mouse, Recombinant

Catalog No. TMPJ-00011
Synonyms: Gro-beta, GRO β, GROB, melanoma growth stimulatory activity beta, GRO2, melanoma growth stimulatory activity β, MGSA-beta, SCYB2, MIP2-α, Gro-β, chemokine ligand 2, MIP2-alpha, MGSA-b, cxcl2, Macrophage Inflammatory Protein-2-α, Growth-regulated protein β, Growth-regulated protein beta, GRO beta, MGSA-β, Macrophage Inflammatory Protein-2-alpha, MIP2A, MIP-2, C-X-C motif chemokine 2

C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CXCL2 Protein, Mouse, Recombinant
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,970.00
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Biological Description
Technical Params
Product Properties
Description C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.
Species Mouse
Expression System E. coli
Tag None
Accession Number P10889
Synonyms Gro-beta, GRO β, GROB, melanoma growth stimulatory activity beta, GRO2, melanoma growth stimulatory activity β, MGSA-beta, SCYB2, MIP2-α, Gro-β, chemokine ligand 2, MIP2-alpha, MGSA-b, cxcl2, Macrophage Inflammatory Protein-2-α, Growth-regulated protein β, Growth-regulated protein beta, GRO beta, MGSA-β, Macrophage Inflammatory Protein-2-alpha, MIP2A, MIP-2, C-X-C motif chemokine 2
Amino Acid Ala28-Asn100
Construction Recombinant Mouse C-X-C Motif Chemokine 2 is produced by our E.coli expression system and the target gene encoding Ala28-Asn100 is expressed.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 10 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.

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Keywords

CXCL2 Protein, Mouse, Recombinant Gro-beta GRO β GROB melanoma growth stimulatory activity beta MIP2 GRO2 SCYB-2 melanoma growth stimulatory activity β GRO 2 MGSA-beta MIP 2 SCYB2 SCYB 2 MIP2-α GRO-2 Gro-β chemokine ligand 2 MIP2-alpha MGSA-b cxcl2 Macrophage Inflammatory Protein-2-α Growth-regulated protein β Growth-regulated protein beta GRO beta MGSA-β Macrophage Inflammatory Protein-2-alpha MIP2A MIP-2 C-X-C motif chemokine 2 recombinant recombinant-proteins proteins protein

 

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