GRO beta/CXCL2 Protein, Mouse, Recombinant (His)

Name: GRO beta/CXCL2 Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-04789
Rating: 4.5 (1 reviews)

(Synonyms: Scyb2, Scyb, MIP-2a, MIP-2, Mip2, Mgsa-b, GROb, Gro2, GRO β/CXCL2, CINC-2a, chemokine (C-X-C motif) ligand 2) Copy Product Info

Synonyms: Scyb2, Scyb, MIP-2a, MIP-2, Mip2, Mgsa-b, GROb, Gro2, GRO β/CXCL2, CINC-2a, chemokine (C-X-C motif) ligand 2

Catalog No. TMPY-04789 Copy Product Info

GRO beta/CXCL2 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.2 kDa and the accession number is P10889.

Pack Size	Price	USA Stock	Global Stock
5 µg	$98	7-10 days	7-10 days
10 µg	$165	7-10 days	7-10 days
20 µg	$233	7-10 days	7-10 days
50 µg	$383	7-10 days	7-10 days
100 µg	$659	7-10 days	7-10 days
200 µg	$1,080	7-10 days	7-10 days
500 µg	$2,330	7-10 days	7-10 days
1 mg	$4,660	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	GRO beta/CXCL2 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.2 kDa and the accession number is P10889.
Species	Mouse
Expression System	P. pastoris (Yeast)
Tag	C-His
Accession Number	P10889
Construction	A DNA sequence encoding the mouse Cxcl2 (NP_033166.1) (Ala28-Asn100) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 28
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 30% CAN. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	Scyb2, Scyb, MIP-2a, MIP-2, Mip2, Mgsa-b, GROb, Gro2, GRO β/CXCL2, CINC-2a, chemokine (C-X-C motif) ligand 2
Research Background	Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.

Chemical Properties

Molecular Weight

9.2 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.