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5-A-RU-PABC-Val-Cit-Fmoc

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Catalog No. T40303Cas No. 2677841-58-4

5-A-RU-PABC-Val-Cit-Fmoc is a precursor of 5-A-RU, a small molecule activator associated with mucosal-associated invariant T (MAIT) cells and a precursor in bacterial riboflavin synthesis.

5-A-RU-PABC-Val-Cit-Fmoc

5-A-RU-PABC-Val-Cit-Fmoc

🥰Excellent
Purity: 98.7%
Catalog No. T40303Cas No. 2677841-58-4
5-A-RU-PABC-Val-Cit-Fmoc is a precursor of 5-A-RU, a small molecule activator associated with mucosal-associated invariant T (MAIT) cells and a precursor in bacterial riboflavin synthesis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$299-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.7%
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Product Introduction

Bioactivity
Description
5-A-RU-PABC-Val-Cit-Fmoc is a precursor of 5-A-RU, a small molecule activator associated with mucosal-associated invariant T (MAIT) cells and a precursor in bacterial riboflavin synthesis.
In vitro
Analysis of both in vitro and in vivo prodrugs showed that compared to 5-A-RU, 5-A-RU-PABC-Val-Cit-Fmoc induces higher levels of mucosa-associated invariant T (MAIT) cell activation.[1].
Chemical Properties
Molecular Weight903.93
FormulaC43H53N9O13
Cas No.2677841-58-4
SmilesCC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Nc2c(NC[C@H](O)[C@H](O)[C@H](O)CO)[nH]c(=O)[nH]c2=O)cc1
Relative Density.1.47 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (88.5 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.65 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1063 mL5.5314 mL11.0628 mL55.3140 mL
5 mM0.2213 mL1.1063 mL2.2126 mL11.0628 mL
10 mM0.1106 mL0.5531 mL1.1063 mL5.5314 mL
20 mM0.0553 mL0.2766 mL0.5531 mL2.7657 mL
50 mM0.0221 mL0.1106 mL0.2213 mL1.1063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

5-A-RU-PABC-Val-Cit-Fmoc5ARUPABCValCitFmoc5 A RU PABC Val Cit Fmoc
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