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B-Raf IN 2

Name: B-Raf IN 2
Brand: TargetMol
SKU: T40284
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T40284Cas No. 2649372-20-1

B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.

B-Raf IN 2

🥰Excellent

Purity: 98.86%

Catalog No. T40284Cas No. 2649372-20-1

B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.

Pack Size	Price	Availability
1 mg	$52	In Stock
5 mg	$127	In Stock
10 mg	$198	In Stock
25 mg	$353	In Stock
50 mg	$495	In Stock
100 mg	$696	In Stock

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Batch Information

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Purity:98.86%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.
In vitro	B-Raf IN 2 demonstrates significantly reduced paradoxical activation of the MAPK signaling pathway while maintaining high efficacy [1].

Chemical Properties

Molecular Weight	461.44
Formula	C₂₀H₁₇F₂N₅O₄S
Cas No.	2649372-20-1
Smiles	Cn1cnc2ccc(Oc3c(F)ccc(NS(=O)(=O)N4CC[C@@H](F)C4)c3C#N)cc2c1=O
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (195.0 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1671 mL	10.8356 mL	21.6713 mL	108.3564 mL
5 mM	0.4334 mL	2.1671 mL	4.3343 mL	21.6713 mL
10 mM	0.2167 mL	1.0836 mL	2.1671 mL	10.8356 mL
20 mM	0.1084 mL	0.5418 mL	1.0836 mL	5.4178 mL
50 mM	0.0433 mL	0.2167 mL	0.4334 mL	2.1671 mL
100 mM	0.0217 mL	0.1084 mL	0.2167 mL	1.0836 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc