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MEDI-2045
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Catalog No. T9901A-1310 Copy Product Info
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MEDI-2045 is a humanized monoclonal antibody targeting the interleukin-4 receptor alpha subunit (IL-4Ra). IL-4Ra is a pivotal receptor driving Type 2 inflammation, serving as an essential component of the shared receptor complexes for both IL-4 and IL-13. By specifically binding to IL-4Ra, this antibody dually blocks IL-4 and IL-13 signaling, thereby inhibiting the downstream JAK-STAT signaling pathway. This mechanism significantly attenuates inflammation involved in Th2 cell activation, B-cell class switching to IgE, and eosinophil recruitment, making it a critical tool for immunological research in asthma, atopic dermatitis, and other allergic diseases.
Cas No. 2241728-76-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $398 | Inquiry | Inquiry | |
| 5 mg | $1,190 | Inquiry | Inquiry | |
| 10 mg | $1,890 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Chemical Properties
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| Description | MEDI-2045 is a humanized monoclonal antibody targeting the interleukin-4 receptor alpha subunit (IL-4Ra). IL-4Ra is a pivotal receptor driving Type 2 inflammation, serving as an essential component of the shared receptor complexes for both IL-4 and IL-13. By specifically binding to IL-4Ra, this antibody dually blocks IL-4 and IL-13 signaling, thereby inhibiting the downstream JAK-STAT signaling pathway. This mechanism significantly attenuates inflammation involved in Th2 cell activation, B-cell class switching to IgE, and eosinophil recruitment, making it a critical tool for immunological research in asthma, atopic dermatitis, and other allergic diseases. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | IL-4Ra/CD124 |
| Cas No. | 2241728-76-5 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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