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CB2R PAM

Name: CB2R PAM
Brand: TargetMol
SKU: T37075
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37075Cas No. 2244579-87-9

Alias Ec2la

CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.

CB2R PAM

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Purity: 99.09%

Catalog No. T37075Alias Ec2laCas No. 2244579-87-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$295	In Stock	In Stock
50 mg	$448	In Stock	In Stock
100 mg	$659	In Stock	In Stock
500 mg	$1,380	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.09%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.
In vitro	CB2R Positive Allosteric Modulator (PAM) at a concentration of 100 nM notably enhances the capability of CP55940 and 2-AG, without affecting AEA, in promoting [35S]GTPγS binding to CB2 receptors.[1]
In vivo	CB2R PAM (1-20 mg/kg; p.o.) exhibits antinociceptive activity. [1]
Synonyms	Ec2la

Chemical Properties

Molecular Weight	435.33
Formula	C₂₁H₂₄BrFN₂O₂
Cas No.	2244579-87-9
Smiles	N(C(=O)C1CCCCCC1)C=2C(=O)N(CC3=CC=C(F)C=C3)C=C(Br)C2C
Color	Green
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (103.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.59 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2971 mL	11.4855 mL	22.9711 mL	114.8554 mL
5 mM	0.4594 mL	2.2971 mL	4.5942 mL	22.9711 mL
10 mM	0.2297 mL	1.1486 mL	2.2971 mL	11.4855 mL
20 mM	0.1149 mL	0.5743 mL	1.1486 mL	5.7428 mL
50 mM	0.0459 mL	0.2297 mL	0.4594 mL	2.2971 mL
100 mM	0.0230 mL	0.1149 mL	0.2297 mL	1.1486 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc