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CB2R PAM

Name: CB2R PAM
Brand: TargetMol
SKU: T37075
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37075Cas No. 2244579-87-9

Alias Ec2la

CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.

CB2R PAM

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Purity: 99.09%

Catalog No. T37075Alias Ec2laCas No. 2244579-87-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$295	In Stock	In Stock
50 mg	$448	In Stock	In Stock
100 mg	$659	In Stock	In Stock
500 mg	$1,380	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.09%

Appearance:Solid

Color:Green

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.
In vitro	CB2R Positive Allosteric Modulator (PAM) at a concentration of 100 nM notably enhances the capability of CP55940 and 2-AG, without affecting AEA, in promoting [35S]GTPγS binding to CB2 receptors.[1]
In vivo	CB2R PAM (1-20 mg/kg; p.o.) exhibits antinociceptive activity. [1]
Synonyms	Ec2la

Chemical Properties

Molecular Weight	435.33
Formula	C₂₁H₂₄BrFN₂O₂
Cas No.	2244579-87-9
Smiles	N(C(=O)C1CCCCCC1)C=2C(=O)N(CC3=CC=C(F)C=C3)C=C(Br)C2C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (103.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2971 mL	11.4855 mL	22.9711 mL	114.8554 mL
5 mM	0.4594 mL	2.2971 mL	4.5942 mL	22.9711 mL
10 mM	0.2297 mL	1.1486 mL	2.2971 mL	11.4855 mL
20 mM	0.1149 mL	0.5743 mL	1.1486 mL	5.7428 mL
50 mM	0.0459 mL	0.2297 mL	0.4594 mL	2.2971 mL
100 mM	0.0230 mL	0.1149 mL	0.2297 mL	1.1486 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc