Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors, but has no effect in the absence of agonists. ...CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 179.00 | |
25 mg | In stock | $ 295.00 | |
50 mg | In stock | $ 448.00 | |
100 mg | In stock | $ 659.00 | |
500 mg | In stock | $ 1,380.00 |
Description | CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors, but has no effect in the absence of agonists. ...CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain. |
In vitro | CB2R Positive Allosteric Modulator (PAM) at a concentration of 100 nM notably enhances the capability of CP55940 and 2-AG, without affecting AEA, in promoting [35S]GTPγS binding to CB2 receptors.[1] |
In vivo | CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity.[1] |
Synonyms | Ec2la |
Molecular Weight | 435.33 |
Formula | C21H24BrFN2O2 |
CAS No. | 2244579-87-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (103.4 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CB2R PAM 2244579-87-9 GPCR/G Protein Cannabinoid Receptor Ec2la inhibitor inhibit