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Ocrelizumab
(Synonyms: IDC-2403, IDC2403) Copy Product Info
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Synonyms: IDC-2403, IDC2403
Catalog No. T77482 Copy Product Info
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Ocrelizumab (IDC-2403) is a humanized monoclonal antibody directed against CD20 for the treatment of multiple sclerosis.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $245 | In Stock | In Stock | |
| 5 mg | $647 | In Stock | In Stock | |
| 10 mg | $1,038 | - | In Stock | |
| 25 mg | $1,765 | - | In Stock | |
| 50 mg | $2,650 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:93.9% (SDS-PAGE); 98% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Ocrelizumab (IDC-2403) is a humanized monoclonal antibody directed against CD20 for the treatment of multiple sclerosis. |
| In vivo | In a mouse model of multiple sclerosis, Ocrelizumab, administered subcutaneously or intravenously at a dose of 7.5 mg/kg once daily for 18 days, induced B-cell depletion by an antibody-dependent cellular cytotoxicity (ADCC) mechanism to inhibit lesions. In C57BL/6 mice, Ocrelizumab administered intravenously at a dose of 50 μg on days 7, 14, and 21 significantly reduced B and T cells in the blood, lymph nodes, and spleen.[1][2] |
| Synonyms | IDC-2403, IDC2403 |
| Reactivity | Human |
| Verified Activity | Immobilized Human CD20 Protein (His & Avi) (TMPK-00183) at 10 μg/mL (100 μL/well) can bind Ocrelizumab. The EC50 is 528.1 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <0.9 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD20 |
| Molecular Weight | 145.8 kDa |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Ocrelizumab chemical structure | Ocrelizumab in vivo | Ocrelizumab molecular weight
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