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Riluzole hydrochloride

Name: Riluzole hydrochloride
Brand: TargetMol
SKU: T41265
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41265Cas No. 850608-87-6

Alias PK 26124 hydrochloride, AQST-117 hydrochloride

Riluzole hydrochloride (PK 26124 hydrochloride) is an anticonvulsant compound belonging to the family of sodium channel blockers that inhibits GABA uptake.Riluzole hydrochloride is a sodium-glutamate antagonist with anticancer and neuroprotective activity and can be used to study amyotrophic lateral sclerosis and neurological disorders.

Riluzole hydrochloride

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Purity: 99.76%

Catalog No. T41265Alias PK 26124 hydrochloride, AQST-117 hydrochlorideCas No. 850608-87-6

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$31	In Stock	In Stock
50 mg	$44	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Riluzole hydrochloride (PK 26124 hydrochloride) is an anticonvulsant compound belonging to the family of sodium channel blockers that inhibits GABA uptake.Riluzole hydrochloride is a sodium-glutamate antagonist with anticancer and neuroprotective activity and can be used to study amyotrophic lateral sclerosis and neurological disorders.
Targets&IC50	GABA receptor:43 μM
In vitro	Riluzole hydrochloride (20-100 μM) significantly prolonged the decay of IPSCs, resulting in almost no change in the total charge transfer[1].
In vivo	Riluzole hydrochloride (8 mg/kg;i.p.) can inhibit auditory and aversive emotional responses in adult rats with arthritis, but does not affect spinal withdrawal thresholds[2].
Synonyms	PK 26124 hydrochloride, AQST-117 hydrochloride

Chemical Properties

Molecular Weight	270.66
Formula	C₈H₆ClF₃N₂OS
Cas No.	850608-87-6
Smiles	Cl.Nc1nc2ccc(OC(F)(F)F)cc2s1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (295.57 mM), Sonication is recommended.

H2O: 2 mg/mL (7.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6947 mL	18.4734 mL	36.9467 mL	184.7336 mL
5 mM	0.7389 mL	3.6947 mL	7.3893 mL	36.9467 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3695 mL	1.8473 mL	3.6947 mL	18.4734 mL
20 mM	0.1847 mL	0.9237 mL	1.8473 mL	9.2367 mL
50 mM	0.0739 mL	0.3695 mL	0.7389 mL	3.6947 mL
100 mM	0.0369 mL	0.1847 mL	0.3695 mL	1.8473 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc