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Catumaxomab
🥰Excellent
Catalog No. T78307Cas No. 509077-98-9
Alias LP-000, LP000
Catumaxomab （LP-000） is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM (Epithelial Cell Adhesion Molecule) for the treatment of malignant ascites in cancer patients.
Catumaxomab
Catumaxomab
🥰Excellent
Purity: 95%
Catalog No. T78307Alias LP-000, LP000Cas No. 509077-98-9
Catumaxomab （LP-000） is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM (Epithelial Cell Adhesion Molecule) for the treatment of malignant ascites in cancer patients.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $328 | In Stock | |
| 5 mg | $859 | In Stock | |
| 10 mg | $1,380 | In Stock | |
| 25 mg | $1,980 | In Stock |
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Concentration:7.06 mg/mL
Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Catumaxomab （LP-000） is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM (Epithelial Cell Adhesion Molecule) for the treatment of malignant ascites in cancer patients. |
| In vitro | Catumaxomab inhibits the growth of FaDu tumor spheroids co-cultured with PBMCs in a dose-dependent manner when treated at concentrations ranging from 0 to 5 ng/mL for 3 to 7 days [1]. |
| In vivo | Catumaxomab was administered intraperitoneally to patients with EpCAM-positive cancers and malignant ascites on days 0, 3, 7, and 10 at escalating doses of 10, 20, 50, and 150 μg, respectively. The treatment significantly prolonged puncture-free survival, reduced the number of EpCAM-positive tumor cells and VEGF levels in ascitic fluid, and enhanced the activation of CD4⁺ and CD8⁺ T cells [2]. |
| Alias | LP-000, LP000 |
| Cas No. | 509077-98-9 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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