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LTBR Protein, Mouse, Recombinant (hFc)
(Synonyms: Tumor necrosis factor receptor superfamily member 3, Tnfrsf3, Tnfcr, Lymphotoxin-β receptor, Lymphotoxin-beta receptor, Ltbr) Copy Product InfoSynonyms: Tumor necrosis factor receptor superfamily member 3, Tnfrsf3, Tnfcr, Lymphotoxin-β receptor, Lymphotoxin-beta receptor, Ltbr
Catalog No. TMPJ-00994 Copy Product Info
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $48 | 7-10 days | 7-10 days | |
| 10 μg | $75 | - | In Stock | |
| 20 μg | $112 | 7-10 days | 7-10 days | |
| 50 μg | $197 | 7-10 days | 7-10 days | |
| 100 μg | $338 | 7-10 days | 7-10 days | |
| 200 μg | $586 | 7-10 days | 7-10 days | |
| 500 μg | $1,220 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 99%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Loaded Mouse LTBR-Fc on Protein A Biosensor, can bind Human LIGHT-His with an affinity constant of 0.81 nM as determined in BLI assay. (Regularly tested)  |
| Description | It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P50284 |
| Amino Acid | Ser28-Pro218 |
| Construction | Ser28-Pro218 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified)  |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Tumor necrosis factor receptor superfamily member 3, Tnfrsf3, Tnfcr, Lymphotoxin-β receptor, Lymphotoxin-beta receptor, Ltbr |
| Research Background |
| Molecular Weight | 61 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: LTBR Protein, Mouse, Recombinant (hFc) chemical structure | LTBR Protein, Mouse, Recombinant (hFc) molecular weight
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