Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2’-O-Methylguanosine-5’-O-triphosphate (2’-methyl GTP) acts as an inhibitor targeting the hepatitis C virus (HCV) non-structural protein 5B (NS5B; with an IC50 of 3.5 µM), and serves as an active metabolite of the prodrug IDX184 through a 2’-methylguanosine intermediate transformation. Additionally, at a concentration of 50 µM, it promotes tubulin polymerization. Notably, levels of 2’-methyl GTP are reduced in the tumoral tissues of patients with hepatocellular carcinoma in comparison to the adjacent normal tissues.
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Description | 2’-O-Methylguanosine-5’-O-triphosphate (2’-methyl GTP) acts as an inhibitor targeting the hepatitis C virus (HCV) non-structural protein 5B (NS5B; with an IC50 of 3.5 µM), and serves as an active metabolite of the prodrug IDX184 through a 2’-methylguanosine intermediate transformation. Additionally, at a concentration of 50 µM, it promotes tubulin polymerization. Notably, levels of 2’-methyl GTP are reduced in the tumoral tissues of patients with hepatocellular carcinoma in comparison to the adjacent normal tissues. |
Synonyms | 2'-methyl GTP, 2'-O-methyl GTP |
Molecular Weight | 625.13 |
Formula | C11H14N5O14P3.4Na |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
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2'-O-Methylguanosine-5'-O-triphosphate sodium 2'-methyl GTP 2'-O-methyl GTP inhibitor inhibit