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Lucatumumab
🥰Excellent
Catalog No. T76729Cas No. 903512-50-5
Alias HCD122, HCD 122, CHIR-12.12
Lucatumumab (HCD122) is a fully human anti-CD40 monoclonal antibody with antitumor activity that blocks the interaction of CD40L with CD40 and inhibits the CD40/CD40L-mediated signaling pathway for the study of chronic lymphocytic leukemia (CLL) and multiple myeloma.
Lucatumumab
Lucatumumab
🥰Excellent
Purity: 95.5% (SDS-PAGE); 98.4% (SEC-HPLC)
Catalog No. T76729Alias HCD122, HCD 122, CHIR-12.12Cas No. 903512-50-5
Lucatumumab (HCD122) is a fully human anti-CD40 monoclonal antibody with antitumor activity that blocks the interaction of CD40L with CD40 and inhibits the CD40/CD40L-mediated signaling pathway for the study of chronic lymphocytic leukemia (CLL) and multiple myeloma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $163 | In Stock | |
| 5 mg | $448 | In Stock | |
| 10 mg | $728 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,480 | In Stock |
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Concentration:5.37 mg/mL
Purity:95.5% (SDS-PAGE); 98.4% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lucatumumab (HCD122) is a fully human anti-CD40 monoclonal antibody with antitumor activity that blocks the interaction of CD40L with CD40 and inhibits the CD40/CD40L-mediated signaling pathway for the study of chronic lymphocytic leukemia (CLL) and multiple myeloma. |
| In vitro | Lucatumumab (0.001-10 μg/mL; 4 hours) lysed B-cell chronic lymphocytic leukemia (B-CLL) cells by antibody-dependent cell-mediated cytotoxicity (ADCC) action, achieving a mean maximum lysis rate of 49%. [1] Lucatumumab (0.1-10 μg/mL; 3 days) was able to decrease CD40L-induced signaling and reduce B-CLL cell viability. [1] Lucatumumab (10 μg/mL; 24 hours) is able to inhibit cytokine secretion by B-CLL cells. [1] |
| Synonyms | HCD122, HCD 122, CHIR-12.12 |
| Cas No. | 903512-50-5 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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