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Netivudine

Catalog No. T60540 CAS 84558-93-0

Netivudine is a potent nucleoside reverse transcriptase inhibitor (NRTIs), a nucleoside analogue with anti-varicella zoster virus activity that can be used to treat human immunodeficiency virus (HIV) infection. Netivudine works by inhibiting reverse transcriptase, which reduces viral load in the body and slows the progression of the disease through its inhibitory effect.

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Netivudine, CAS 84558-93-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 258.00
5 mg	In stock	$ 642.00
10 mg	In stock	$ 913.00
25 mg	In stock	$ 1,370.00
50 mg	In stock	$ 1,850.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 99.83%

Biological Description

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Storage & Solubility Information

Description	Netivudine is a potent nucleoside reverse transcriptase inhibitor (NRTIs), a nucleoside analogue with anti-varicella zoster virus activity that can be used to treat human immunodeficiency virus (HIV) infection. Netivudine works by inhibiting reverse transcriptase, which reduces viral load in the body and slows the progression of the disease through its inhibitory effect.
Targets&IC50	VZV:0.6-3.8μM
In vitro	The phosphorylation of netivudine in VZV infected human cells is similar to that of sorivudine and the IC50 of netivudine for VZV ranges from 06-3.8 uM. Since, in HSV-infected cells, only the monophosphate is formed, netivudine shows no appreciable in vitro activity against HSV or other human herpesviruses.[1]
In vivo	The half-life of netivudine in humans is about 12-15 hand preliminary pharmacokinetic studies, employing oral doses of netivudine at 100 mg, 200 mg and 400 mg in young adults and healthy elderly volunteers, confirmed that concentrations of the drug substantially above the IC50 for VZV could be achieved and sustained with twice daily dosing.[2] The drug bioavailability was 21.1% and 24.6% in the young and elderly, respectively. An initial, open, dose-ranging study of netivudine in 31 elderly immunocompetent patients with localised herpes zoster with oral doses up to 200mg twice daily showed therapeutic benefits upon rash healing and pain and no significant adverse effects.[3]

Molecular Weight	282.25
Formula	C12H14N2O6
CAS No.	84558-93-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Rahim S G, et al. 5-Alkynyl pyrimidine nucleosides as potent selective inhibitors of varicella-zoster virus. Antiviral Chemistry and Chemotherapy. 1992;3(5): 293-297. 2. Peck RW, et al. The bioavailability and disposition of 1-(beta-D-arabinofuranosyl)-5-(1-propynyl)uracil (882C87), a potent, new anti-varicella zoster virus agent. Br J Clin Pharmacol. 1995;39(2):143-149. 3. Wood MJ, et al. Preliminary pharmacokinetics and safety of 882C87 in patients with herpes zoster. J Med Virol. 1993;1:154-157.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Bioactive Compounds Library Max Clinical Compound Library Anti-Cancer Compound Library Bioactive Compound Library DNA Damage & Repair Compound Library

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Keywords

Netivudine 84558-93-0 inhibitor inhibit

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