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diABZI-C2-NH2

Name: diABZI-C2-NH2
Brand: TargetMol
SKU: T39597
Price: 699 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39597Cas No. 2137975-93-8

diABZI-C2-NH2 is an agonist of the interferon gene STING that modulates STING-dependent type I interferon production and can be used to study STING-mediated diseases.

diABZI-C2-NH2

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Purity: 96.09%

Catalog No. T39597Cas No. 2137975-93-8

diABZI-C2-NH2 is an agonist of the interferon gene STING that modulates STING-dependent type I interferon production and can be used to study STING-mediated diseases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$699	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:96.09%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

diABZI-C2-NH2 is an agonist of the interferon gene STING that modulates STING-dependent type I interferon production and can be used to study STING-mediated diseases.

In vitro

diABZIs can enhance binding to STING and cellular function. Intravenous administration of diABZI STING agonists to immunocompetent syngeneic colon tumor-bearing mice induces strong antitumor activity, leading to complete and durable tumor regression. The conjugated diABZI-C2-NH2 can be covalently immobilized onto agarose beads for affinity capture of potential target proteins from THP1 cell lysates[1].

Chemical Properties

Molecular Weight	721.81
Formula	C₃₆H₄₃N₁₃O₄
Cas No.	2137975-93-8
Smiles	CCn1nc(C)cc1C(=O)Nc1nc2cc(ccc2n1CCCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(ccc12)C(=O)NCCN)C(N)=O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (110.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3854 mL	6.9270 mL	13.8541 mL	69.2703 mL
5 mM	0.2771 mL	1.3854 mL	2.7708 mL	13.8541 mL
10 mM	0.1385 mL	0.6927 mL	1.3854 mL	6.9270 mL
20 mM	0.0693 mL	0.3464 mL	0.6927 mL	3.4635 mL
50 mM	0.0277 mL	0.1385 mL	0.2771 mL	1.3854 mL
100 mM	0.0139 mL	0.0693 mL	0.1385 mL	0.6927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc