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diABZI-C2-NH2

Name: diABZI-C2-NH2
Brand: TargetMol
SKU: T39597
Price: 699 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39597Cas No. 2137975-93-8

diABZI-C2-NH2 is an agonist of the interferon gene STING that modulates STING-dependent type I interferon production and can be used to study STING-mediated diseases.

diABZI-C2-NH2

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Purity: 96.09%

Catalog No. T39597Cas No. 2137975-93-8

diABZI-C2-NH2 is an agonist of the interferon gene STING that modulates STING-dependent type I interferon production and can be used to study STING-mediated diseases.

Pack Size	Price	Availability	Quantity
1 mg	$699	In Stock

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Purity:96.09%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

diABZI-C2-NH2 is an agonist of the interferon gene STING that modulates STING-dependent type I interferon production and can be used to study STING-mediated diseases.

In vitro

diABZIs can enhance binding to STING and cellular function. Intravenous administration of diABZI STING agonists to immunocompetent syngeneic colon tumor-bearing mice induces strong antitumor activity, leading to complete and durable tumor regression. The conjugated diABZI-C2-NH2 can be covalently immobilized onto agarose beads for affinity capture of potential target proteins from THP1 cell lysates[1].

Chemical Properties

Molecular Weight	721.81
Formula	C₃₆H₄₃N₁₃O₄
Cas No.	2137975-93-8
Smiles	CCn1nc(C)cc1C(=O)Nc1nc2cc(ccc2n1CCCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(ccc12)C(=O)NCCN)C(N)=O
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (110.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3854 mL	6.9270 mL	13.8541 mL	69.2703 mL
5 mM	0.2771 mL	1.3854 mL	2.7708 mL	13.8541 mL
10 mM	0.1385 mL	0.6927 mL	1.3854 mL	6.9270 mL
20 mM	0.0693 mL	0.3464 mL	0.6927 mL	3.4635 mL
50 mM	0.0277 mL	0.1385 mL	0.2771 mL	1.3854 mL
100 mM	0.0139 mL	0.0693 mL	0.1385 mL	0.6927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc