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Talquetamab

Catalog No. T76882 CAS 2226212-40-2

Synonyms: JNJ-64407564, JNJ-7564

Talquetamab (JNJ-64407564) is a T-cell retargeting GPRC5D bispecific antibody for multiple myeloma with antitumor activity that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation.Talquetamab is used to treat multiple myeloma (MM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Talquetamab, CAS 2226212-40-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
2 mg	In stock	$ 437.00
5 mg	In stock	$ 723.00
10 mg	In stock	$ 1,160.00
25 mg	In stock	$ 1,720.00
50 mg	In stock	$ 2,320.00
100 mg	In stock	$ 3,130.00

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Description	Talquetamab (JNJ-64407564) is a T-cell retargeting GPRC5D bispecific antibody for multiple myeloma with antitumor activity that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation.Talquetamab is used to treat multiple myeloma (MM).
In vitro	Talquetamab, at concentrations ranging from 0.00128 to 4.0 μg/mL for 48 hours, effectively induces lysis of multiple myeloma cells. This induction is accompanied by a significant dose-dependent increase in the proportion of activated CD4+ and CD8+ T cells, as well as elevated levels of granule enzyme B and inflammatory cytokines such as IL-6, IL-8, and TNF-α [2].
In vivo	Talquetamab (JNJ-64407564), administered subcutaneously or intravenously at doses ranging from 0.1 to 50 µg, exhibits significant anti-tumor activity in H929 and MM mouse models [1].

Synonyms	JNJ-64407564, JNJ-7564
Molecular Weight	N/A
CAS No.	2226212-40-2

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store at -20°C

References and Literature

1. Kodandaram Pillarisetti, et al. A T-cell-redirecting bispecific G-protein-coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma. Blood. 2020 Apr 9;135(15):1232-1243. 2. Christie P M Verkleij, et al. Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2196-2215.

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Keywords

Talquetamab 2226212-40-2 GPCR/G Protein Neuroscience Dopamine Receptor JNJ-64407564 JNJ-7564 inhibitor inhibit

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