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Talquetamab
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Catalog No. T76882Cas No. 2226212-40-2
Alias JNJ-7564, JNJ-64407564
Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
Talquetamab
😃Good
Catalog No. T76882Alias JNJ-7564, JNJ-64407564Cas No. 2226212-40-2
Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $289 | In Stock | In Stock | |
| 2 mg | $437 | - | In Stock | |
| 5 mg | $723 | In Stock | In Stock | |
| 10 mg | $1,160 | - | In Stock | |
| 25 mg | $1,720 | - | In Stock | |
| 50 mg | $2,320 | - | In Stock | |
| 100 mg | $3,130 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.6% (SDS-PAGE); 99.7% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
| Description | Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity. |
| In vitro | Talquetamab, at concentrations ranging from 0.00128 to 4.0 μg/mL for 48 hours, effectively induces lysis of multiple myeloma cells. This induction is accompanied by a significant dose-dependent increase in the proportion of activated CD4+ and CD8+ T cells, as well as elevated levels of granule enzyme B and inflammatory cytokines such as IL-6, IL-8, and TNF-α [2]. |
| In vivo | Talquetamab (JNJ-64407564), administered subcutaneously or intravenously at doses ranging from 0.1 to 50 µg, exhibits significant anti-tumor activity in H929 and MM mouse models [1]. |
| Synonyms | JNJ-7564, JNJ-64407564 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | GPRC5D & CD3 |
| Molecular Weight | 144.59 kDa |
| Cas No. | 2226212-40-2 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | IgG4 |
| Recommended Isotype Control |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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