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Otamixaban

Name: Otamixaban
Brand: TargetMol
SKU: T16410
Price: 299 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16410Cas No. 193153-04-7

Alias XRP 0673, RPR 130673, FXV-673, FXV673, FXV 673

Otamixaban (FXV673) is a selective and highly effective Xa inhibitor that inhibits the generation of thrombin and can be used to study acute coronary syndrome.

Otamixaban

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Purity: 98.08%

Catalog No. T16410Alias XRP 0673, RPR 130673, FXV-673, FXV673, FXV 673Cas No. 193153-04-7

Otamixaban (FXV673) is a selective and highly effective Xa inhibitor that inhibits the generation of thrombin and can be used to study acute coronary syndrome.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$299	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.08%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Otamixaban (FXV673) is a selective and highly effective Xa inhibitor that inhibits the generation of thrombin and can be used to study acute coronary syndrome.
Targets&IC50	TMPRSS2:18.7 × 10 μM
In vitro	The HTS assay indicates that otamixaban shows inhibitory activity against TMPRSS2. IC50= 18.7 × 10 μM. Otamixaban in the Calu-3 cell line inhibits SARS-CoV-2 S-mediated viral entry. [5]
In vivo	Otamixaban is highly efficacious in rodent, canine and porcine models of thrombosis showed in vivo experiments. Recent clinical findings indicate that Otamixaban is efficacious, safe, and well-tolerated in humans and therefore has considerable potential for the treatment of acute coronary syndrome.
Synonyms	XRP 0673, RPR 130673, FXV-673, FXV673, FXV 673

Chemical Properties

Molecular Weight	446.5
Formula	C₂₅H₂₆N₄O₄
Cas No.	193153-04-7
Smiles	C(N[C@@H]([C@@H](CC1=CC(C(=N)N)=CC=C1)C(OC)=O)C)(=O)C2=CC=C(C=C2)C=3C=CN(=O)=CC3
Relative Density.	1.25 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (89.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2396 mL	11.1982 mL	22.3964 mL	111.9821 mL
5 mM	0.4479 mL	2.2396 mL	4.4793 mL	22.3964 mL
10 mM	0.2240 mL	1.1198 mL	2.2396 mL	11.1982 mL
20 mM	0.1120 mL	0.5599 mL	1.1198 mL	5.5991 mL
50 mM	0.0448 mL	0.2240 mL	0.4479 mL	2.2396 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc