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OG-L002 hydrochloride
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Catalog No. T89353Cas No. 1357299-45-6
OG-L002 hydrochloride is an effective and highly selective inhibitor of LSD1, with an IC50 of 0.02 µM. Additionally, it serves as an efficient monoamine oxidase (MAO) inhibitor, exhibiting IC50 values of 1.38 µM for MAO-A and 0.72 µM for MAO-B. This compound also effectively suppresses the expression of the HSV1E gene.
OG-L002 hydrochloride
😃Good
Catalog No. T89353Cas No. 1357299-45-6
OG-L002 hydrochloride is an effective and highly selective inhibitor of LSD1, with an IC50 of 0.02 µM. Additionally, it serves as an efficient monoamine oxidase (MAO) inhibitor, exhibiting IC50 values of 1.38 µM for MAO-A and 0.72 µM for MAO-B. This compound also effectively suppresses the expression of the HSV1E gene.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | OG-L002 hydrochloride is an effective and highly selective inhibitor of LSD1, with an IC50 of 0.02 µM. Additionally, it serves as an efficient monoamine oxidase (MAO) inhibitor, exhibiting IC50 values of 1.38 µM for MAO-A and 0.72 µM for MAO-B. This compound also effectively suppresses the expression of the HSV1E gene. |
| In vitro | OG-L002 effectively suppresses viral immediate-early (IE) gene expression in cells, displaying a significantly lower half-maximal inhibitory concentration (IC 50) compared to the control monoamine oxidase inhibitor TCP. The IC 50 values are approximately 10 μM in HeLa cells and about 3 μM in human foreskin fibroblast (HFF) cells, whereas TCP shows an IC 50 of around 1 mM. |
| In vivo | Administered intraperitoneally at doses ranging from 6-40 mg/kg daily for a week, OG-L002 effectively reduces the presence of viral genomes within the ganglia, exhibiting dose-dependent efficacy observed at both 3 and 5 days after infection. OG-L002 acts as a potent, highly selective inhibitor of LSD1, with an IC 50 of 0.02 μM, and demonstrates significant inhibitory effects on monoamine oxidases (MAO), with IC 50 values of 1.38 μM for MAO-A and 0.72 μM for MAO-B, respectively. Additionally, OG-L002 strongly suppresses the expression of HSV IE genes. |
| Molecular Weight | 261.75 |
| Formula | C15H16ClNO |
| Cas No. | 1357299-45-6 |
| Smiles | N[C@@H]1[C@H](C1)C2=CC=C(C=C2)C3=CC(O)=CC=C3.Cl |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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