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Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R. Ianalumab can inhibit the interaction between BAFF and BAFF-R and inhibit the protection of apoptosis mediated by BAFF. Ianalumab has antibody dependent cytotoxicity (ADCC) and works by activating effector cells mediated by the immune receptor tyrosine activation motif (ITAM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 222.00 | |
5 mg | In stock | $ 553.00 | |
10 mg | In stock | $ 796.00 | |
25 mg | In stock | $ 1,220.00 | |
50 mg | In stock | $ 1,650.00 | |
100 mg | In stock | $ 2,220.00 |
Description | Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R. Ianalumab can inhibit the interaction between BAFF and BAFF-R and inhibit the protection of apoptosis mediated by BAFF. Ianalumab has antibody dependent cytotoxicity (ADCC) and works by activating effector cells mediated by the immune receptor tyrosine activation motif (ITAM). |
In vitro | Ianalumab (0.1 μg/mL; 72 h) exhibits potent antibody-dependent cell-mediated cytotoxicity (ADCC) against natural killer cells in chronic lymphocytic leukemia (CLL), promoting the production of cytokines[1]. |
In vivo |
Ianalumab (total dose: 100 mg/kg; once a week; for 2 weeks) increases the survival rate in a mouse model of chronic lymphocytic leukemia (CLL)[1]. Ianalumab (10 mg/kg; once a week; for 6 weeks), when modulated with Ibrutinib, demonstrates enhanced functionality of NK cells[1]. |
Synonyms | VAY-736 |
Molecular Weight | N/A |
CAS No. | 1929549-92-7 |
store at low temperature
store at -80°C
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Ianalumab 1929549-92-7 Others VAY736 VAY 736 VAY-736 inhibitor inhibit