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Ianalumab (Synonyms: VAY-736)
Catalog No. T77370 Copy Product Info
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Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R that inhibits the interaction between BAFF and BAFF-R, blocking BAFF-mediated apoptosis protection. Ianalumab exhibits antibody-dependent cytotoxicity (ADCC) and activates effector cells via the immune receptor tyrosine activation motif (ITAM).
Ianalumab
Copy Product Info🥰Excellent
Catalog No. T77370
Synonyms VAY-736
Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R that inhibits the interaction between BAFF and BAFF-R, blocking BAFF-mediated apoptosis protection. Ianalumab exhibits antibody-dependent cytotoxicity (ADCC) and activates effector cells via the immune receptor tyrosine activation motif (ITAM).
Ianalumab
Cas No. 1929549-92-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $222 | - | In Stock | |
| 5 mg | $553 | - | In Stock | |
| 10 mg | $796 | - | In Stock | |
| 25 mg | $1,220 | - | In Stock | |
| 50 mg | $1,650 | - | In Stock | |
| 100 mg | $2,220 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R that inhibits the interaction between BAFF and BAFF-R, blocking BAFF-mediated apoptosis protection. Ianalumab exhibits antibody-dependent cytotoxicity (ADCC) and activates effector cells via the immune receptor tyrosine activation motif (ITAM). |
| In vitro | Ianalumab (0.1 μg/mL; 72 h) demonstrates significant antibody-dependent cell-mediated cytotoxicity (ADCC) against natural killer cells in chronic lymphocytic leukemia (CLL), enhancing cytokine production[1]. |
| In vivo | Ianalumab (total dose: 100 mg/kg; once a week; for 2 weeks) increases the survival rate in a mouse model of chronic lymphocytic leukemia (CLL)[1]. Ianalumab (10 mg/kg; once a week; for 6 weeks), when modulated with Ibrutinib, demonstrates enhanced functionality of NK cells[1]. |
| Synonyms | VAY-736 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFRSF13C/BAFFR/CD268 |
| Molecular Weight | 146.44 kDa |
| Cas No. | 1929549-92-7 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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