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DBCO-PEG4-VC-PAB-MMAE

Name: DBCO-PEG4-VC-PAB-MMAE
Brand: TargetMol
SKU: T39576
Price: 145 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T39576 Copy Product Info

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DBCO-PEG4-VC-PAB-MMAE is a drug-linker complex consisting of an ADC linker (DBCO-PEG4-VC-PAB) and the tubulin polymerization inhibitor MMAE. It is a key building block utilized for the synthesis of antibody-drug conjugates (ADCs). MMAE, a synthetic derivative of dolastatin 10, functions as a potent mitotic inhibitor by blocking tubulin polymerization. The reagent features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules via click chemistry. The VC-PAB (Valine-Citrulline-p-aminobenzylcarbamate) moiety is a Cathepsin B-cleavable linker, ensuring site-specific drug release within the lysosomal environment of target cells.

DBCO-PEG4-VC-PAB-MMAE

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Catalog No. T39576

Cas No. 2129164-91-4

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$145	-	In Stock
5 mg	$362	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:Yellow

Resource Download

COA

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	1658.06
Formula	C₈₈H₁₂₈N₁₂O₁₉
Cas No.	2129164-91-4
Smiles	C(CCC(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(N([C@H](C(N[C@H](C(N([C@H]([C@@H](CC(=O)N2[C@]([C@@H]([C@H](C(N[C@@H]([C@@H](O)C3=CC=CC=C3)C)=O)C)OC)(CCC2)[H])OC)[C@H](CC)C)C)=O)[C@H](C)C)=O)C(C)C)C)=O)C=C1)=O)CCCNC(N)=O)=O)[C@@H](C)C)=O)=O)(=O)N4C=5C(C#CC=6C(C4)=CC=CC6)=CC=CC5
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120.00 mg/mL (72.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6031 mL	3.0156 mL	6.0311 mL	30.1557 mL
5 mM	0.1206 mL	0.6031 mL	1.2062 mL	6.0311 mL
10 mM	0.0603 mL	0.3016 mL	0.6031 mL	3.0156 mL
20 mM	0.0302 mL	0.1508 mL	0.3016 mL	1.5078 mL
50 mM	0.0121 mL	0.0603 mL	0.1206 mL	0.6031 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc