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Pascolizumab

Catalog No. T77426 CAS 331243-22-2

Synonyms: SB-240683

Pascolizumab (SB-240683) is a humanized monoclonal antibody against IL-4. Pascolizumab has asthmatic effects and can be used to study allergic rhinitis.

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Pascolizumab

Pascolizumab, CAS 331243-22-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 755.00
10 mg	In stock	$ 1,180.00
25 mg	In stock	$ 1,780.00
50 mg	In stock	$ 2,390.00
100 mg	In stock	$ 3,250.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pascolizumab (SB-240683) is a humanized monoclonal antibody against IL-4. Pascolizumab has asthmatic effects and can be used to study allergic rhinitis.
Targets&IC50	T cells:157pM, Tonsillar B cells:377 pM
In vitro	Pascolizumab binds to IL-4 and inhibits the interaction between IL-4 and its receptor alpha chain[1]. Pascolizumab (0-10000 pM; 3 days) demonstrates anti-proliferative activity with IC50 values of 157 pM for T cells and 377 pM for tonsillar B cells[1].

Synonyms	SB-240683
Molecular Weight	N/A
CAS No.	331243-22-2

Storage

store at low temperature

store at -80°C

References and Literature

1. Hart TK, et al. Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol. 2002 Oct;130(1):93-100.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pascolizumab 331243-22-2 Immunology/Inflammation IL Receptor SB-240683 SB 240683 SB240683 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.