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WJ-39

🥰Excellent
Catalog No. T84345Cas No. 3009908-95-3
Alias WJ39, WJ 39

WJ-39 is an orally active aldose reductase (AR) inhibitor that ameliorates renal lesions in diabetic nephropathy through activation of Nrf2 signaling, and may be used to ameliorate renal insufficiency and fibrosis.WJ-39 inhibits oxidative stress and inhibits the activation of the inflammatory vesicle of the oligomerization structural domain-like receptor family, pyrin structural domain 3 (NLRP3).

WJ-39

WJ-39

🥰Excellent
Purity: 99.45%
Catalog No. T84345Alias WJ39, WJ 39Cas No. 3009908-95-3
WJ-39 is an orally active aldose reductase (AR) inhibitor that ameliorates renal lesions in diabetic nephropathy through activation of Nrf2 signaling, and may be used to ameliorate renal insufficiency and fibrosis.WJ-39 inhibits oxidative stress and inhibits the activation of the inflammatory vesicle of the oligomerization structural domain-like receptor family, pyrin structural domain 3 (NLRP3).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$117In StockIn Stock
5 mg$289In StockIn Stock
10 mg$463In StockIn Stock
25 mg$928In StockIn Stock
50 mg$1,480In StockIn Stock
100 mg$2,360In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.45%
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Product Introduction

Bioactivity
Description
WJ-39 is an orally active aldose reductase (AR) inhibitor that ameliorates renal lesions in diabetic nephropathy through activation of Nrf2 signaling, and may be used to ameliorate renal insufficiency and fibrosis.WJ-39 inhibits oxidative stress and inhibits the activation of the inflammatory vesicle of the oligomerization structural domain-like receptor family, pyrin structural domain 3 (NLRP3).
SynonymsWJ39, WJ 39
Chemical Properties
Molecular Weight430.32
FormulaC19H14Cl2KNO4
Cas No.3009908-95-3
SmilesO=C(CN1C=C(CC2=C(Cl)C(Cl)=CC=C2)C(C3=CC(OC)=CC=C31)=O)[O-].[K+]
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (232.39 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3239 mL11.6193 mL23.2385 mL116.1926 mL
5 mM0.4648 mL2.3239 mL4.6477 mL23.2385 mL
10 mM0.2324 mL1.1619 mL2.3239 mL11.6193 mL
20 mM0.1162 mL0.5810 mL1.1619 mL5.8096 mL
50 mM0.0465 mL0.2324 mL0.4648 mL2.3239 mL
100 mM0.0232 mL0.1162 mL0.2324 mL1.1619 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

aldose reductase
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