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AM12814
Catalog No. T213522 Copy Product Info
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AM12814 is a potent partial agonist for the CB1 and CB2 receptors, with Ki values of 0.7 nM and 3.4 nM, respectively. It inhibits cAMP accumulation and recruits β-arrestin 2. AM12814 exhibits cannabinoid-like effects and can be used in research on neurological disorders, such as catalepsy.
AM12814
Copy Product Info🥰Excellent
Catalog No. T213522
AM12814 is a potent partial agonist for the CB1 and CB2 receptors, with Ki values of 0.7 nM and 3.4 nM, respectively. It inhibits cAMP accumulation and recruits β-arrestin 2. AM12814 exhibits cannabinoid-like effects and can be used in research on neurological disorders, such as catalepsy.
AM12814
Cas No. 3054511-18-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AM12814 is a potent partial agonist for the CB1 and CB2 receptors, with Ki values of 0.7 nM and 3.4 nM, respectively. It inhibits cAMP accumulation and recruits β-arrestin 2. AM12814 exhibits cannabinoid-like effects and can be used in research on neurological disorders, such as catalepsy. |
| Targets&IC50 | CB1 receptor (rat):0.7 nM (Ki) |
| In vitro | AM12814 (Compound 12) binds with high affinity to cannabinoid receptors, exhibiting K i values of 0.7 nM for rCB1 and 3.4 nM for hCB2. Within 30 minutes, AM12814 inhibits the Forskolin-induced accumulation of cAMP in 3xHA-hCB1-CHO and 3xHA-hCB2-CHO cells, with EC 50 values of 8.75 nM and 22 nM, respectively. After 90 minutes, the compound recruits β-arrestin 2 in hCB1-DRx-CHO and hCB2-DRx-U2OS cells, with EC 50 values of 25 nM and 5.6 nM, respectively. |
| In vivo | AM12814 (Compound 12), administered at a dose of 0.3-3 mg/kg via intraperitoneal injection, induces CB1-mediated cannabinoid-like behaviors in CD1 mice. |
| Molecular Weight | 429.57 |
| Formula | C24H38F3NO2 |
| Cas No. | 3054511-18-8 |
| Smiles | [C@H](/C=C\CCCCC(F)(F)F)(/C=C\C/C=C\C/C=C\CCCC(N[C@@H](CO)C)=O)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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