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MC-Val-Cit-PAB-Exatecan

Name: MC-Val-Cit-PAB-Exatecan
Brand: TargetMol
SKU: T77847
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77847Cas No. 2504068-28-2

Alias MC-Val-Cit-PAB-DX8951

MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) consists of a cytotoxin, the topoisomerase I inhibitor DX-8951, and a linker sensitive to cathepsin, forming a drug-linker conjugate for antibody-drug conjugates (ADCs).

MC-Val-Cit-PAB-Exatecan

🥰Excellent

Purity: 98.03%

Catalog No. T77847Alias MC-Val-Cit-PAB-DX8951Cas No. 2504068-28-2

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$340	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.03%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) consists of a cytotoxin, the topoisomerase I inhibitor DX-8951, and a linker sensitive to cathepsin, forming a drug-linker conjugate for antibody-drug conjugates (ADCs).
In vitro	ADC consists of an antibody to which the cytotoxic agent is attached via a linker [1].
Synonyms	MC-Val-Cit-PAB-DX8951

Chemical Properties

Molecular Weight	1034.09
Formula	C₅₃H₆₀FN₉O₁₂
Cas No.	2504068-28-2
Smiles	N(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN2C(=O)C=CC2=O)=O)[C@H](C)C)=O)CCCNC(N)=O)=O)C=C1)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (77.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9670 mL	4.8352 mL	9.6703 mL	48.3517 mL
5 mM	0.1934 mL	0.9670 mL	1.9341 mL	9.6703 mL
10 mM	0.0967 mL	0.4835 mL	0.9670 mL	4.8352 mL
20 mM	0.0484 mL	0.2418 mL	0.4835 mL	2.4176 mL
50 mM	0.0193 mL	0.0967 mL	0.1934 mL	0.9670 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc