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Canakinumab
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Catalog No. T73695Cas No. 914613-48-2
Alias Ilaris, ACZ 885
Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody that inhibits human and chorioallantoic monkey IL-1β with IC50 values of 43.6 and 40.8 pM, respectively. It exhibits anti-inflammatory activity by neutralizing IL-1β signaling, and it has been used for the treatment of gout and coronary artery disease.
Canakinumab
😃Good
Catalog No. T73695Alias Ilaris, ACZ 885Cas No. 914613-48-2
Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody that inhibits human and chorioallantoic monkey IL-1β with IC50 values of 43.6 and 40.8 pM, respectively. It exhibits anti-inflammatory activity by neutralizing IL-1β signaling, and it has been used for the treatment of gout and coronary artery disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $179 | In Stock | In Stock | |
| 5 mg | $579 | In Stock | In Stock | |
| 10 mg | $826 | In Stock | In Stock | |
| 25 mg | $1,220 | - | In Stock | |
| 50 mg | $1,650 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.8% (SDS-PAGE); 98.3% (SEC-HPLC)
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| Description | Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody that inhibits human and chorioallantoic monkey IL-1β with IC50 values of 43.6 and 40.8 pM, respectively. It exhibits anti-inflammatory activity by neutralizing IL-1β signaling, and it has been used for the treatment of gout and coronary artery disease. |
| Targets&IC50 | IL-1β:43.6 pM (human), IL-1β:40.8 pM (marmoset) |
| In vitro | Dose-dependently, Canakinumab (0-7 nM) represses IL-6 production in marmoset peripheral blood mononuclear cells, demonstrating IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively[2]. Effectively, Canakinumab competes with IL-1RI and IL-1RII for binding to IL-1b[2]. |
| Synonyms | Ilaris, ACZ 885 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IL-1b |
| Molecular Weight | 145.18 kDa |
| Cas No. | 914613-48-2 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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