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Canakinumab (Synonyms: Ilaris, ACZ 885)
Catalog No. T73695 Copy Product Info
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Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody that inhibits human and chorioallantoic monkey IL-1β with IC50 values of 43.6 and 40.8 pM, respectively. It exhibits anti-inflammatory activity by neutralizing IL-1β signaling, and it has been used for the treatment of gout and coronary artery disease.
Canakinumab
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Catalog No. T73695
Synonyms Ilaris, ACZ 885
Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody that inhibits human and chorioallantoic monkey IL-1β with IC50 values of 43.6 and 40.8 pM, respectively. It exhibits anti-inflammatory activity by neutralizing IL-1β signaling, and it has been used for the treatment of gout and coronary artery disease.
Cas No. 914613-48-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $179 | In Stock | In Stock | |
| 5 mg | $579 | In Stock | In Stock | |
| 10 mg | $826 | In Stock | In Stock | |
| 25 mg | $1,220 | - | In Stock | |
| 50 mg | $1,650 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.8% (SDS-PAGE); 98.3% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody that inhibits human and chorioallantoic monkey IL-1β with IC50 values of 43.6 and 40.8 pM, respectively. It exhibits anti-inflammatory activity by neutralizing IL-1β signaling, and it has been used for the treatment of gout and coronary artery disease. |
| Targets&IC50 | IL-1β:40.8 pM (marmoset), IL-1β:43.6 pM (human) |
| In vitro | Dose-dependently, Canakinumab (0-7 nM) represses IL-6 production in marmoset peripheral blood mononuclear cells, demonstrating IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively[2]. Effectively, Canakinumab competes with IL-1RI and IL-1RII for binding to IL-1b[2]. |
| Synonyms | Ilaris, ACZ 885 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IL-1 beta/IL-1F2 Protein (TMPY-01049) at 2 μg/mL (100 μL/well) can bind Canakinumab. The EC50 is 9.61 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IL-1b |
| Molecular Weight | 145.18 kDa |
| Cas No. | 914613-48-2 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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