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6-Azuridine

Name: 6-Azuridine
Brand: TargetMol
SKU: TNU0022
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TNU0022Cas No. 54-25-1

Alias 6-Azuridine

6-Azauridine (6-Azuridine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.6-Azuridine's anticancer mechanism is dependent on the inhibition of DNA synthesis.

6-Azuridine

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Purity: 99.02%

Catalog No. TNU0022Alias 6-AzuridineCas No. 54-25-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$40	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.02%

Appearance:Solid

Color:Yellow

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COA HPLC HNMR

Product Introduction

6-Azuridine AI Summary

6-Azuridine exhibits a broad range of antiviral activities against various viruses including West Nile Virus, Dengue virus, Respiratory syncytial virus (RSV), Yellow fever virus (YFV), Chikungunya virus, and others, with effective concentration (EC50) values ranging from 468.0 nM to over 25000.0 nM. It also shows moderate antifungal and antibacterial activities against specific pathogens. The compound has demonstrated significant in vivo efficacy, notably increasing the lifespan of mice with L1210 leukemia by over 25% at a dose of 400 mg/kg. In terms of cytotoxicity, 6-Azuridine exhibits varying levels of toxicity against different cell lines such as Vero cells, MT4 cells, and murine leukemia L1210 cells, with cytotoxic concentration (CC50) values ranging from 200.0 nM to greater than 100000.0 nM, indicating a generally lower cytotoxicity at higher concentrations. The selectivity indices calculated suggest a favorable therapeutic window for treatments against specific viruses such as RSV and YFV. 6-Azuridine also demonstrates inhibitory activities against Plasmodium species and yeast, and is capable of targeting various biological processes including cancer cell targeting with p53 mutations and modulating miRNA expression. Although it exhibits no significant inhibition against SARS-CoV-2, the compound's broad spectrum of activity against other viral and microbial pathogens indicates its potential as a valuable antiviral and antimicrobial agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	6-Azauridine (6-Azuridine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.6-Azuridine's anticancer mechanism is dependent on the inhibition of DNA synthesis.
Synonyms	6-Azuridine

Chemical Properties

Molecular Weight	245.19
Formula	C₈H₁₁N₃O₆
Cas No.	54-25-1
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc(=O)[nH]c1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (224.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0785 mL	20.3923 mL	40.7847 mL	203.9235 mL
5 mM	0.8157 mL	4.0785 mL	8.1569 mL	40.7847 mL
10 mM	0.4078 mL	2.0392 mL	4.0785 mL	20.3923 mL
20 mM	0.2039 mL	1.0196 mL	2.0392 mL	10.1962 mL
50 mM	0.0816 mL	0.4078 mL	0.8157 mL	4.0785 mL
100 mM	0.0408 mL	0.2039 mL	0.4078 mL	2.0392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc