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8-Bromoguanosine

Name: 8-Bromoguanosine
Brand: TargetMol
SKU: T7924
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7924Cas No. 4016-63-1

8-Bromoguanosine is a brominated derivative of guanosine. It is activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.

8-Bromoguanosine

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Purity: 99.62%

Catalog No. T7924Cas No. 4016-63-1

8-Bromoguanosine is a brominated derivative of guanosine. It is activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.62%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

8-Bromoguanosine AI Summary

8-Bromoguanosine induces the proliferation of CBA/CaJ mice spleen cells in vitro, evidenced by increased DNA synthesis at varying concentrations. It enhances murine NK cell activity in vivo, promoting cytotoxicity against YAC-1 cells at different target ratios. The compound exhibits efficacy against Semliki Forest virus infection in mice, improving survival rates and mean survival times at specific doses. Additionally, 8-Bromoguanosine inhibits cellular replication and differentiation in Friend erythroleukemia cells, achieving an ID50 of 5.1 mM and reducing the percentage of benzidine-positive cells to 6.0% at an optimal concentration of 5.0 mM. As a purine nucleoside phosphorylase inhibitor, it demonstrates 12.0% activity in human erythrocyte assays, with a Km value of 9400000.0 nM based on Lineweaver-Burk plot analysis, measured via ribose release after 30 minutes using the orcinol reaction relative to guanosine..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

8-Bromoguanosine is a brominated derivative of guanosine. It is activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.

Chemical Properties

Molecular Weight	362.14
Formula	C₁₀H₁₂BrN₅O₅
Cas No.	4016-63-1
Smiles	NC1=NC(=O)C2=C(N1)N(C1OC(CO)C(O)C1O)C(Br)=N2
Relative Density.	2.62 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (55.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7614 mL	13.8068 mL	27.6136 mL	138.0682 mL
5 mM	0.5523 mL	2.7614 mL	5.5227 mL	27.6136 mL
10 mM	0.2761 mL	1.3807 mL	2.7614 mL	13.8068 mL
20 mM	0.1381 mL	0.6903 mL	1.3807 mL	6.9034 mL
50 mM	0.0552 mL	0.2761 mL	0.5523 mL	2.7614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc