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hMAO-B-IN-4

🥰Excellent
Catalog No. T67764Cas No. 1666119-75-0

hMAO-B-IN-4 is a selective, reversible and blood–brain barrier (BBB) penetrable inhibitor of human monoamine oxidase-B (hMAO-B, IC50=0.067 μM, Ki= 0.03 μM, hMAO-A, IC50= 33.82 μM).

hMAO-B-IN-4

hMAO-B-IN-4

🥰Excellent
Purity: 99.8%
Catalog No. T67764Cas No. 1666119-75-0
hMAO-B-IN-4 is a selective, reversible and blood–brain barrier (BBB) penetrable inhibitor of human monoamine oxidase-B (hMAO-B, IC50=0.067 μM, Ki= 0.03 μM, hMAO-A, IC50= 33.82 μM).
Pack SizePriceAvailabilityQuantity
5 mg$38In Stock
10 mg$58In Stock
25 mg$118In Stock
50 mg$197In Stock
100 mg$323In Stock
200 mg$460In Stock
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Purity:99.8%
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Product Introduction

Bioactivity
Description
hMAO-B-IN-4 is a selective, reversible and blood–brain barrier (BBB) penetrable inhibitor of human monoamine oxidase-B (hMAO-B, IC50=0.067 μM, Ki= 0.03 μM, hMAO-A, IC50= 33.82 μM).
Targets&IC50
MAO-B (human):0.067 μM, MAO-A (human):33.82 μM, MAO-B (human):0.03 μM (Ki)
In vitro
hMAO-B-IN-4 (0-40 μM) shows high selectivity for hMAO-B over hMAO-A, with an SI value of 504.791, and inhibits hMAO-A and hMAO-B with IC50 values of 33.821 μM and 0.067 μM, respectively[1].
Chemical Properties
Molecular Weight320.4
FormulaC20H16O2S
Cas No.1666119-75-0
SmilesO=C(\C=C\c1ccc(OCc2ccccc2)cc1)c1cccs1
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.2 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1211 mL15.6055 mL31.2110 mL156.0549 mL
5 mM0.6242 mL3.1211 mL6.2422 mL31.2110 mL
10 mM0.3121 mL1.5605 mL3.1211 mL15.6055 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

hMAO-B-IN-4hMAOBIN4hMAO-B
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