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Myxochelin A

Catalog No. T35692 CAS 120243-02-9

Myxochelin A is a microbial metabolite that has been found inA. disciformisand has diverse biological activities.1It is active against Gram-positive bacteria, includingB. cereus,S. aureus, andM. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-Lipoxygenase (5-LO) activity with an IC50value of 1.9 μM for the recombinant human enzyme.2It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/ml.3

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Myxochelin A, CAS 120243-02-9

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1 mg	Inquiry	$ 489.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Myxochelin A is a microbial metabolite that has been found inA. disciformisand has diverse biological activities.1It is active against Gram-positive bacteria, includingB. cereus,S. aureus, andM. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50value of 1.9 μM for the recombinant human enzyme.2It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/ml.3

Molecular Weight	404.419
Formula	C20H24N2O7
CAS No.	120243-02-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Methanol: Soluble

Ethanol: Soluble

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kunze, B., Bedorf, N., Kohl, W., et al.Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological propertiesJ. Antibiot. (Tokyo)42(1)14-17(1989) 2. Schieferdecker, S., K?nig, S., Koeberle, A., et al.Myxochelins target human 5-lipoxygenaseJ. Nat. Prod.78(2)335-338(2015) 3. Miyanaga, S., Obata, T., Onaka, H., et al.Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861J. Antibiot. (Tokyo)59(11)698-703(2006)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Myxochelin A 120243-02-9 inhibitor inhibit

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