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Milbemycin A3

Name: Milbemycin A3
Brand: TargetMol
SKU: T35746
Price: 168 USD
Availability: InStock
Rating: 5 (10 reviews)

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Milbemycin A3 is a macrocyclic lactone compound produced by fermentation of Streptomyces hygroscopicus, characterized by a spiroketal structure. It enhances the activity of Glutamate-gated chloride channel and GABA-gated chloride channels, thereby disrupting neurotransmission in parasites and exhibiting acaricidal and nematocidal activities.

Cas No. 51596-10-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$168	-	In Stock
5 mg	$419	-	In Stock
10 mg	$668	-	In Stock
25 mg	$1,330	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Milbemycin A3 is a macrocyclic lactone compound produced by fermentation of Streptomyces hygroscopicus, characterized by a spiroketal structure. It enhances the activity of Glutamate-gated chloride channel and GABA-gated chloride channels, thereby disrupting neurotransmission in parasites and exhibiting acaricidal and nematocidal activities.
Targets & IC50	C. elegans:9.5 μg/ml, spider mite eggs:41.1 μg/ml, adult spider mites:5.3 μg/ml

Chemical Properties

Molecular Weight	528.69
Formula	C₃₁H₄₄O₇
Cas No.	51596-10-2
Smiles	C[C@H](C/C(C)=C/C[C@]1([H])C[C@]([H])(O2)C[C@]3(CC[C@H](C)[C@@H](C)O3)O1)/C=C\C=C(CO4)/[C@@]([C@@]4([H])[C@H](O)C(C)=C5)(O)[C@]5([H])C2=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: Soluble

DMF: Soluble

DMSO: 26.67 mg/mL (50.45 mM), Sonication is recommended.

Ethanol: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8915 mL	9.4573 mL	18.9147 mL	94.5734 mL
5 mM	0.3783 mL	1.8915 mL	3.7829 mL	18.9147 mL
10 mM	0.1891 mL	0.9457 mL	1.8915 mL	9.4573 mL
20 mM	0.0946 mL	0.4729 mL	0.9457 mL	4.7287 mL
50 mM	0.0378 mL	0.1891 mL	0.3783 mL	1.8915 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.